Antidiabetic and antihyperlipidemic activities of Cucumis melo var. momordica fruit extract on experimental animals

Future Journal of Pharmaceutical Sciences

Table 4 Antihyperlipidemic activity of C. melo fraction and extracts

Groups	Dose (mg/kg)	TG (mg/dl)	LDL (mg/dl)	VLDL (mg/dl)	HDL (mg/dl)
Negative control	–	71.83 ± 0.7	72.83 ± 0.72	10.65 ± 0.49	48.32 ± 1.9
Positive control	–	117.66 ± 1.47*	159.55 ± 1.03*	47.12 ± 0.93*	18.08 ± 1.28*
Reference	10	78.16 ± 1.56△	76.26 ± 0.32 △	14.09 ± 0.69△	45.86 ± 1.47△
CMTF	50	84.16 ± 0.7△	86.97 ± 0.34△	19.73 ± 1.2△	38.76 ± 2.68△
CMEE 1	400	92.22 ± 0.84△	97.01 ± 1.05△	22.83 ± 0.33△	38.61 ± 63△
CMEE 2	200	102.33 ± 0.29	113.16 ± 0.89	38.87 ± 1.13	44.33 ± 0.32
CMAE 1	400	100.13 ± 0.23	105.16 ± 0.56	29.45 ± 0.05	42.05 ± 0.14
CMAE 2	200	105.12 ± 0.46	116.49 ± 1.10	41.54 ± 0.45	44.1 ± 0.43

Values are expressed as mean ± standard error of mean (n = 6), significantly different at *P < 0.05, vs the normal control group; △P < 0.05, vs the diabetic control group analyzed by one-way ANOVA followed by Tukey’s multiple comparison test
CMTF Cucumis melo toluene fraction (ethanolic extract), CMEE 1 Cucumis melo ethanolic extract (400 mg/kg), CMEE 2 Cucumis melo ethanolic extract (200 mg/kg), CMAE 1 Cucumis melo aqueous extract (400 mg/kg), CMAE 2 Cucumis melo aqueous extract (200 mg/kg)