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Future Journal of Pharmaceutical Sciences

Table 2 Enzyme kinetics for the inhibition of aldose reductase and sorbitol dehydrogenase by pawpaw (Carica papaya) fruit extract

From: Carica papaya Linn. fruit extract inhibited the activities of aldose reductase and sorbitol dehydrogenase: possible mechanism for amelioration of diabetic complications

Enzyme

Sample

Km (mM)

Vmax (mM/min)

Aldose reductase

Control

0.33

0.10

Pawpaw

1.16

0.11

Sorbitol dehydrogenase

Control

0.35

0.42

Pawpaw

0.42

2.04

  1. Values presented were obtained from the double reciprocal plot prepared using GraphPad Prism statistical package. Km Michaelis constant, Vmax maximum velocity of reaction
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