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Table 1 Organoleptic properties and solubility of chondroitin sulfate (CS) and glucosamine sulfate (GlcN). The data represent the qualitative analysis obtained from pharmacy and technical specifications provided by the suppliers (S1 and S2). All methods of performing these analyses were carried out according to the Brazilian pharmacopeia specifications and analytical data from post-marketing [25] and recognized by the Brazilian Health Regulatory Agency (ANVISA), responsible for pharmaceutical product regulation in Brazil [20]

From: Fourier-transformed infrared spectroscopy, physicochemical and biochemical properties of chondroitin sulfate and glucosamine as supporting information on quality control of raw materials

Samples

 

Pharmacy (S1 samples)

Pharmacy (S2 samples)

Supplier 1 (S1)

Supplier 2 (S1)

Control quality

Control quality

CS

Organoleptic characteristics

White powder; characteristic odor

White powder; characteristic odor

Fine white amorphous powder, cream or ivory; characteristic odor

Powder cream to nearly white amorphous thin ivory, moderately hygroscopic

Solubility

Water-soluble

Water-soluble

Water-soluble

Water-soluble

GlcN

Organoleptic characteristics

Almost white powder

Almost white powder

White crystalline powder

Cream-colored powder almost white

Solubility

Soluble in water and practically insoluble in alcohol

Soluble in water and practically insoluble in alcohol

Easily soluble in water and practically insoluble in ethanol

Soluble in water and practically insoluble in acetone, alcohol, and isopropyl alcohol