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Table 3 Experimental and predicted responses of formulations with their coded factors

From: Development of nitazoxanide-loaded colon-targeted formulation for intestinal parasitic infections: centre composite design-based optimization and characterization

Formulation code Independent variables Dependent variables
Coded factors Observed responses Predicted responses
X1 X2 Y1 Y2 Y3 Y1 Y2 Y3
Factorial points
 F1  1  1 700.72 72.13 79.13 696.75 72.36 78.85
 F3  1 + 1 672.87 76.13 83.12 673.83 76.38 83.48
 F7 + 1  1 848.36 86.31 82.17 847.50 86.18 81.52
 F9 + 1 + 1 750.62 90.17 90.54 754.69 90.07 90.52
Centre points
 F5 0 0 892.78 83.17 88.67 892.98 83.42 88.09
Axial points
 F2  1 0 688.23 75.28 81.22 691.25 74.80 81.14
 F4 0  1 911.12 81.12 83.78 915.95 81.02 84.71
 F6 0 + 1 863.12 85.13 91.87 858.09 84.98 91.53
 F8 + 1 0 810.27 88.32 85.32 807.06 88.55 85.99
Optimized nitazoxanide-loaded chitosan microbeads
 Optimized nitazoxanide microbeads (FF1) 3.184 2.250 829.14 ± 1.03 90.84 ± 0.64 89.75 ± 0.38 809.649 89.071 91.662