Table 3 Experimental and predicted responses of formulations with their coded factors
Formulation code | Independent variables | Dependent variables | ||||||
|---|---|---|---|---|---|---|---|---|
Coded factors | Observed responses | Predicted responses | ||||||
X1 | X2 | Y1 | Y2 | Y3 | Y1 | Y2 | Y3 | |
Factorial points | ||||||||
F1 | − 1 | − 1 | 700.72 | 72.13 | 79.13 | 696.75 | 72.36 | 78.85 |
F3 | − 1 | + 1 | 672.87 | 76.13 | 83.12 | 673.83 | 76.38 | 83.48 |
F7 | + 1 | − 1 | 848.36 | 86.31 | 82.17 | 847.50 | 86.18 | 81.52 |
F9 | + 1 | + 1 | 750.62 | 90.17 | 90.54 | 754.69 | 90.07 | 90.52 |
Centre points | ||||||||
F5 | 0 | 0 | 892.78 | 83.17 | 88.67 | 892.98 | 83.42 | 88.09 |
Axial points | ||||||||
F2 | − 1 | 0 | 688.23 | 75.28 | 81.22 | 691.25 | 74.80 | 81.14 |
F4 | 0 | − 1 | 911.12 | 81.12 | 83.78 | 915.95 | 81.02 | 84.71 |
F6 | 0 | + 1 | 863.12 | 85.13 | 91.87 | 858.09 | 84.98 | 91.53 |
F8 | + 1 | 0 | 810.27 | 88.32 | 85.32 | 807.06 | 88.55 | 85.99 |
Optimized nitazoxanide-loaded chitosan microbeads | ||||||||
Optimized nitazoxanide microbeads (FF1) | 3.184 | 2.250 | 829.14 ± 1.03 | 90.84 ± 0.64 | 89.75 ± 0.38 | 809.649 | 89.071 | 91.662 |