Skip to main content

Table 5 Results of in-silico ADME properties and toxicity data recorded for drug and degradation products using Swiss ADME

From: Characterization and toxicity evaluation of degradation products of febantel

Compound

GI absorption

BBB permeant

PgP substrate

CYP1A2 inhibitor

CYP2C19 inhibitor

CYP2C9 inhibitor

CYP2D6 inhibitor

CYP3A4 inhibitor

Febantel

Low

No

No

No

Yes

Yes

No

No

DP-I

Low

No

Yes

No

Yes

Yes

No

No

DP-II

Low

No

No

No

Yes

Yes

No

No

DP-III

High

No

No

No

No

Yes

No

No

DP-IV

High

No

No

Yes

Yes

Yes

Yes

Yes

DP-V

Low

No

No

No

Yes

Yes

No

No