From: Design, statistical optimization of Nizatidine floating tablets using natural polymer
Factor | Coefficient of estimate | p value | SE | 95% CI Low | 95% CI Low | VIF |
---|---|---|---|---|---|---|
Mimosa gum (2%) | ||||||
Response Y1 (floating lag time): linear model | ||||||
Intercept | 9.10 (Ī²0) | <ā0.0001* | 0.3063 | 8.38 | 9.82 | Ā |
X1-Mimosa (2%) | 3.83(Ī²1) | <ā0.0001* | 0.3954 | 2.90 | 4.77 | 1 |
X2-Sodium bicarbonate | āā4.17 (Ī²2) | <ā0.0001* | 0.3954 | āā5.10 | āā3.23 | 1 |
Response Y2 (swelling index): linear model | ||||||
Intercept | 16.77 (Ī²0) | <ā0.0001* | 0.2330 | 16.22 | 17.32 | Ā |
X1-Mimosa (2%) | āā3.92 (Ī²1) | <ā0.0001* | 0.3008 | āā4.63 | āā3.21 | 1 |
X2-Sodium bicarbonate | 4.20 | <ā0.0001* | 0.3008 | 3.49 | 4.91 | 1 |
Response Y3 (T100): Linear model | ||||||
Intercept | 16.30 (Ī²0) | <ā0.0001* | 0.16 | 15.92 | 16.68 | Ā |
X1-Mimosa (2%) | 5.17 (Ī²1) | <ā0.0001* | 0.21 | 4.68 | 5.65 | 1 |
X2-Sodium bicarbonate | āā1.17 | 0.0007 | 0.20 | āā1.65 | āā0.68 | 1 |
Mimosa gum (1%) | ||||||
Response Y1 (floating lag time): linear model | ||||||
Intercept | 5.80 (Ī²0) | 0.0002 | 0.3767 | 4.91 | 6.69 | Ā |
X1-Mimosa (1%) | 3.17(Ī²1) | 0.0003 | 0.4863 | 2.02 | 4.32 | 1 |
X2-Sodium bicarbonate | āā2.50 (Ī²2) | 0.0013 | 0.4863 | āā3.65 | āā1.35 | 1 |
Response Y2 (swelling index): Quadratic model | ||||||
Intercept | 21.76(Ī²0) | <ā0.0001 | 0.1889 | 21.23 | 22.28 | Ā |
X1-Mimosa (1%) | āā1.18(Ī²1) | 0.0008 | 0.1290 | āā1.54 | āā0.8251 | 1.0000 |
X2-Sodium bicarbonate | 4.02(Ī²2) | <ā0.0001 | 0.1290 | 3.66 | 4.37 | 1.0000 |
X1X2 | 0.2500(Ī²12) | 0.1888** | 0.1580 | āā0.1887 | 0.6887 | 1.0000 |
X1X1 | 0.1357(Ī²11) | 0.5477** | 0.2069 | āā0.4387 | 0.7102 | 1.03 |
X2X2 | āā2.16(Ī²22) | <ā0.0001 | 0.2069 | āā2.74 | āā1.59 | 1.03 |
Response Y3 (T100): quadratic model | ||||||
Intercept | 7.21 (Ī²0) | 0.0001* | 0.2088 | 6.63 | 7.79 | Ā |
X1-Mimosa (1%) | 2.83(Ī²1) | 0.0001 | 0.1426 | 2.44 | 3.23 | 1 |
X2-Sodium bicarbonate | āā0.833 (Ī²2) | 0.0043 | 0.1426 | āā1.23 | āā0.43 | 1 |
X1X2 | āā0.2500 (Ī²12) | 0.2256** | 0.1747 | āā0.73 | 0.23 | 1 |
X1X1 | 1.57(Ī²11) | 0.0023 | 0.2287 | 0.93 | 2.21 | 1.03 |
X2X2 | āā0.428 (Ī²22) | 0.1342** | 0.2287 | āā1.06 | 0.206 | 1.03 |