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Table 10 Model coefficients of EGFMT

From: Design, statistical optimization of Nizatidine floating tablets using natural polymer

Factor

Coefficient of estimate

p value

SE

95% CI

Low

95% CI

Low

VIF

Mimosa gum (2%)

Response Y1 (floating lag time): linear model

Intercept

9.10 (Ī²0)

<ā€‰0.0001*

0.3063

8.38

9.82

Ā 

X1-Mimosa (2%)

3.83(Ī²1)

<ā€‰0.0001*

0.3954

2.90

4.77

1

X2-Sodium bicarbonate

āˆ’ā€‰4.17 (Ī²2)

<ā€‰0.0001*

0.3954

āˆ’ā€‰5.10

āˆ’ā€‰3.23

1

Response Y2 (swelling index): linear model

Intercept

16.77 (Ī²0)

<ā€‰0.0001*

0.2330

16.22

17.32

Ā 

X1-Mimosa (2%)

āˆ’ā€‰3.92 (Ī²1)

<ā€‰0.0001*

0.3008

āˆ’ā€‰4.63

āˆ’ā€‰3.21

1

X2-Sodium bicarbonate

4.20

<ā€‰0.0001*

0.3008

3.49

4.91

1

Response Y3 (T100): Linear model

Intercept

16.30 (Ī²0)

<ā€‰0.0001*

0.16

15.92

16.68

Ā 

X1-Mimosa (2%)

5.17 (Ī²1)

<ā€‰0.0001*

0.21

4.68

5.65

1

X2-Sodium bicarbonate

āˆ’ā€‰1.17

0.0007

0.20

āˆ’ā€‰1.65

āˆ’ā€‰0.68

1

Mimosa gum (1%)

Response Y1 (floating lag time): linear model

Intercept

5.80 (Ī²0)

0.0002

0.3767

4.91

6.69

Ā 

X1-Mimosa (1%)

3.17(Ī²1)

0.0003

0.4863

2.02

4.32

1

X2-Sodium bicarbonate

āˆ’ā€‰2.50 (Ī²2)

0.0013

0.4863

āˆ’ā€‰3.65

āˆ’ā€‰1.35

1

Response Y2 (swelling index): Quadratic model

Intercept

21.76(Ī²0)

<ā€‰0.0001

0.1889

21.23

22.28

Ā 

X1-Mimosa (1%)

āˆ’ā€‰1.18(Ī²1)

0.0008

0.1290

āˆ’ā€‰1.54

āˆ’ā€‰0.8251

1.0000

X2-Sodium bicarbonate

4.02(Ī²2)

<ā€‰0.0001

0.1290

3.66

4.37

1.0000

X1X2

0.2500(Ī²12)

0.1888**

0.1580

āˆ’ā€‰0.1887

0.6887

1.0000

X1X1

0.1357(Ī²11)

0.5477**

0.2069

āˆ’ā€‰0.4387

0.7102

1.03

X2X2

āˆ’ā€‰2.16(Ī²22)

<ā€‰0.0001

0.2069

āˆ’ā€‰2.74

āˆ’ā€‰1.59

1.03

Response Y3 (T100): quadratic model

Intercept

7.21 (Ī²0)

0.0001*

0.2088

6.63

7.79

Ā 

X1-Mimosa (1%)

2.83(Ī²1)

0.0001

0.1426

2.44

3.23

1

X2-Sodium bicarbonate

āˆ’ā€‰0.833 (Ī²2)

0.0043

0.1426

āˆ’ā€‰1.23

āˆ’ā€‰0.43

1

X1X2

āˆ’ā€‰0.2500 (Ī²12)

0.2256**

0.1747

āˆ’ā€‰0.73

0.23

1

X1X1

1.57(Ī²11)

0.0023

0.2287

0.93

2.21

1.03

X2X2

āˆ’ā€‰0.428 (Ī²22)

0.1342**

0.2287

āˆ’ā€‰1.06

0.206

1.03

  1. T100 time to release 100% of drug, SE standard error, CI confidence interval, VIF variance of inflation factor *Significant (p < 0.05); ** not significant (p > 0.05)