Table 11 Formulae of optimized EGFMT
From: Design, statistical optimization of Nizatidine floating tablets using natural polymer
Quantity (mg/tablet) ingredients | M2%opt | M1%opt |
|---|---|---|
Nizatidine | 85.00 | 85.00 |
Mimosa (2%) (X1) | 170 | – |
Mimosa (1%) (X1) | – | 194.7 |
Sodium bicarbonate (X2) | 38.25 (15%) | 29.08 (10.4%) |
Aerosil | 2.00 | 2.00 |
Magnesium stearate | 1.00 | 1.00 |
Total | 296.25 | 312 |
Characteristics | ||
FLT (s) | 9.1 | 10.3 |
SWI | 16.7 | 16.3 |
T100 | 12 | 11.039 |
TFT (h) | 14 | 13 |
Uniformity of weighta (mg) | 296.5 ± 0.67 | 312 ± 1.24 |
Uniformity of contentb (%) | 100.09 ± 0.25 | 101.04 ± 1.09 |
Hardnessc (kg/cm2) | 4.5 | 4.6 |
Friability (%) | 0.09 | 0.01 |