Design, statistical optimization of Nizatidine floating tablets using natural polymer

Future Journal of Pharmaceutical Sciences

Table 8 Summary of model statistics for responses Y₁, Y₂, and Y₃

Model R²	R²	Adjusted R²	Predicted R²	PRESS	s.d.	F value	p value	Remarks
Mimosa (2%) based EGFMT
Response Y₁ (floating lag time)
Linear	0.9670	0.9576	0.9311	13.70	0.9686	102.51	< 0.0001	Suggested
Interactive	0.9783	0.9674	0.9613	7.70	0.8482	3.13	0.1274
Quadratic	0.9904	0.9783	0.9318	13.57	0.6922	2.50	0.1971
Response Y₂ (swelling index at 1 h)
Linear	0.9812	0.9758	0.9600	21.10	0.7367	182.29	< 0.0001	Suggested
Interactive	0.9820	0.9729	0.9312	13.87	0.7788	0.2638	0.6259
Quadratic	0.9915	0.9786	0.8954	8.07	0.6986	1.79	0.2781
Response Y₃ (T₁₀₀) time to release 100% of drug
Linear	0.9896	0.9866	0.9790	4.00	0.50	333.49	< 0.0001	Suggested
Interactive	0.9911	0.9866	0.9810	3.24	0.50	0.98	0.358
Quadratic	0.9971	0.9935	0.9765	3.57	0.35	4.2	0.1036
Mimosa (1%) based EGFMT
Response Y₁ (floating lag time)
Linear	0.9077	0.8813	0.7743	40.76	1.19	34.41	0.0002	Suggested
Interactive	0.9449	0.9173	0.8091	20.55	0.9944	4.04	0.0910
Quadratic	0.9637	0.9183	0.6212	24.28	0.9880	1.04	0.4331
Response Y₂ (swelling index at 1 h)
Linear	0.8999	0.8713	0.8000	23.38	1.29	31.47	0.0003
Interactive	0.9021	0.8513	0.6526	4.37	1.38	0.1310	0.7298
Quadratic	0.9966	0.9923	0.9626	40.61	0.3160	55.32	0.0012	Suggested
Response Y₃ (T₁₀₀): time to release 100% of drug
Linear	0.8885	0.8567	0.7929	12.20	0.96	23.89	0.0005
Interactive	0.8928	0.8391	0.7426	4.00	1.03	0.24	0.6433
Quadratic	0.9917	0.9814	0.9321	15.16	0.34	27.88	0.0005	Suggested