Design, statistical optimization of Nizatidine floating tablets using natural polymer

Future Journal of Pharmaceutical Sciences

Table 9 ANOVA for the responses of Mimosa 2% and 1% based EGFMT

Source	SS	df	MS	F value	p value
Mimosa 2%-response Y₁ (linear model)
Model	192.33	2	96.17	102.51	< 0.0001*
X₁-Mimosa 2%	88.17	1	88.17	93.98	< 0.0001*
X₂-Sodium bicarbonate	104.17	1	104.17	111.04	< 0.0001*
Residual	6.57	7	0.9381
Total	198.90	9
Response Y₂ (linear model)
Model	197.88	2	98.94	182.29	< 0.0001*
X₁-Mimosa 2%	92.04	1	92.04	169.58	< 0.0001*
X₂-Sodium bicarbonate	105.84	1	105.84	195.00	< 0.0001*
Residual	3.80	7	0.5428
Total	201.68	9
Response Y₃ (linear model)
Model	168.33	2	84.17	333.4	< 0.0001*
X₁-Mimosa 2%	160.17	1	160.17	634.6	< 0.0001*
X₂-Sodium bicarbonate	8.17	1	8.17	32.4	0.0007*
Residual	1.77	7	0.28
Total	170	9
Mimosa 1%-response Y₁ (linear model)
Model	97.67	2	48.83	34.41	0.0002
X₁-Mimosa 1%	60.17	1	60.17	42.20	0.0003
X₂-Sodium bicarbonate	37.50	1	37.50	26.43	0.0013
Residual	9.93	7	1.42
Total	107.60	9
Response Y₂ (quadratic model)
Model	116.50	5	23.30	233.29	< 0.0001*
X₁- Mimosa 1%	8.40	1	8.40	84.12	0.0008
X₂-Sodium bicarbonate	96.80	1	96.80	969.17	< 0.0001*
X₁X₂	0.2500	1	0.2500	2.50	0.1888**
X₁X₁	0.0430	1	0.0430	0.4303	0.5477**
X₂X₂	10.93	1	10.93	109.43	0.0005
Residual	0.3995	4	0.0999
Total	116.90	9
Response Y₃ (quadratic model)
Model	58.41	5	11.68	95.74	0.0003*
X₁-Mimosa 1%	48.17	1	48.17	394.73	0.0001*
X₂-Sodium bicarbonate	4.17	1	4.17	34.51	0.004
X₁X₂	0.25	1	0.25	2.05	0.22**
X₁X₁	5.76	1	5.76	47.22	0.0023
X₂X₂	0.428	1	0.428	3.51	0.1342**
Residual	0.4881	4	0.122
Total	58.90	9