Evaluation of in vitro and in vivo anthelmintic efficacy of Cyperus compressus Linn., a traditionally used anthelmintic plant in parasite-animal models

Future Journal of Pharmaceutical Sciences

Table 1 In vivo anthelmintic effect of C. compressus methanolic root extract* on adult stages of H. diminuta infection in rats

Treatment groups (mg/kg)	EPG (mean ± SEM)		Percentage difference in EPG (A–B)	Worm count at necropsy (mean ± SEM)	Percentage reduction in worm count (%)
Treatment groups (mg/kg)	Pre-treatment 18–20 days (A)	Post-treatment 26–28 days (B)	Percentage difference in EPG (A–B)	Worm count at necropsy (mean ± SEM)	Percentage reduction in worm count (%)
Control	21676 ± 195.22	21923 ± 26.07	1.13	5.0 ± 0.00	0
Plant extract
175	21652 ± 105.29	14303 ± 110.51^ab	− 33.94	4.4 ± 0.24	12
350	22663 ± 119.43	12561 ± 122.27^ab	− 44.57	4.2 ± 0.37	16
700	22583 ± 102.33	8368 ± 192.61^ab	− 61.74	3.8 ± 0.20	24
Praziquantel
5	22000 ± 221.14	3057 ± 48.26^ab	− 86.10	0.6 ± 0.24^a	88

*Administration of plant extract and praziquantel on days 21−25 post-inoculation with five cysticercoids/rat (n = 5)
^ap < 0.001 as compared to control value
^bp < 0.001 as compared to pre-treatment, one-way ANOVA, followed by Tukey’s test