Evaluation of in vitro and in vivo anthelmintic efficacy of Cyperus compressus Linn., a traditionally used anthelmintic plant in parasite-animal models

Future Journal of Pharmaceutical Sciences

Table 2 In vivo anthelmintic effect of C. compressus methanolic root extract* on S. obvelata in mice

Treatment groups (mg/kg)	EPG (mean ± SEM)		Percentage difference in EPG	Worm count at necropsy		Percentage reduction in worm count (%)
Treatment groups (mg/kg)	Pre-treatment (days 1–3)	Post-treatment (days 9–11)	Percentage difference in EPG	Min–Max	Mean ± SEM	Percentage reduction in worm count (%)
Control	28.4 ± 0.87	29.8 ± 0.37	4.9	62–114	90.2 ± 9.07	0
Plant extract
175	26 ± 1.58	22 ± 4.19	− 15.38	42–98	68.2 ± 10.35	24.39
350	25 ± 1.94	20.4 ± 3.14	− 18.4	41–92	65.4 ± 10.94	27.49
700	24.2 ± 1.59	17.2 ± 2.98	− 26.61	40–86	59 ± 7.93	33.85
Albendazole
20	26.4 ± 0.50	4.8 ± 0.37^ab	− 75.75	4–10	8 ± 0.70^a	91.13

*Administration of plant extract and albendazole on days 4–8 after pre-treatment EPG (n = 5)
^ap < 0.001 as compared to control value
^bp < 0.001 as compared to pre-treatment, one-way ANOVA, followed by Tukey’s test