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Future Journal of Pharmaceutical Sciences

Table 1 Effect of EEAS on BUN, creatinine, and uric acid on PCM-induced nephrotoxicity in rats

From: Nephroprotective activity of Annona Squamosa leaves against paracetamol-induced nephrotoxicity in rats: in vitro and in vivo experiments

Group

BUN (mg/dl)

Creatinine (mg/dl)

Uric acid (mg/dl)

Normal

30.89 ± 0.25

5.12 ± 0.008

1.22 ± 0.06

PCM alone

72.17 ± 0.192*

9.13 ± 0.077*

2.05 ± 0.13*

PCM + EEAS(200 mg/kg)

54.2 ± 0.044@@

3.13 ± 0.112@@

1.70 ± 0.06@@

PCM + EEAS (400 mg/kg)

38.5 ± 0.03@@

4.57 ± 0.82@@

1.23 ± 0.03@@

  1. All values were expressed as mean ± SEM, with six animals per group
  2. *PCM-induced one compared with the normal one (P < 0.01)
  3. @@Two different experimental groups compared with the PCM-induced group (P < 0.001)
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