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Table 1 Specificity and selectivity for bexarotene and internal standard (MTR-BA-LC-MS/MS-05)

From: Development and validation of bexarote by bioanalytical methods using liquid chromatography-tandem mass spectroscopy (LC-MS/MS)

Plasma lot ID Specificity (blank) Selectivity (spiked LLOQ) % interference in blank Area ratio S/N ratio (≥ 5)
Analyte IS peak Analyte IS peak Analyte (< 20%) IS (< 5%) Analyte/IS Analyte
MAT-C-0293-III 1805 2581 30,895 1,932,710 5.8424 0.1335 0.0160 101.450
MAT-C-0577-III 1274 930 31,179 1,861,940 4.0861 0.0499 0.0167 118.834
MAT-C-0578-III 1070 1798 29,447 1,823,809 3.6336 0.0986 0.0161 75.245
MAT-C-0579-III 513 1694 27,120 1,813,246 1.8916 0.0934 0.0150 111.258
MAT-C-0580-III 425 506 29,375 1,868,739 1.4468 0.0271 0.0157 129.562
MAT-C-0586-III 1528 1132 25,471 1,774,320 5.9990 0.0638 0.0144 64.867
MAT-C-0544-I(H) 1147 745 28,883 1,769,483 3.9712 0.0421 0.0163 96.481
MAT-6188-I(L) 1396 2263 28,664 1,815,377 4.8702 0.1247 0.0158 95.259
MAT-6198-IX (heparin) 453 1361 27,446 1,825,500 1.6505 0.0746 0.0150 81.708
  Mean 3.71016 0.07863 0.01567  
   SD 0.000731  
   %CV 4.67