Future Journal of Pharmaceutical Sciences

Table 2 Composition and physicochemical characterization of quetiapine loaded microemulsion (QME) and mucoadhesive microemulsion (QMME) (data represents mean ± SD, n = 3)

From: Comparative evaluation of intranasally delivered quetiapine loaded mucoadhesive microemulsion and polymeric nanoparticles for brain targeting: pharmacokinetic and gamma scintigraphy studies

Formulations*	Oil	S_mix^a (% w/w)	Water	Drug loading (%)	Globule size (nm)	PDI	Zeta potential (mV)	pH	Viscosity (cP)
QME	6	44	50	96.18 ± 1.23	29.75 ± 0.99	0.221 ± 0.01	2.77 ± 0.51	5.94 ± 0.08	17.5 ± 0.69
QMME^b	6	44	50	95.43 ± 0.92	35.31 ± 1.71	0.249 ± 0.03	20.29 ± 1.23	4.98 ± 0.12	38.5 ± 1.26

^*Concentration of quetiapine fumarate in each formulation is 23 mg/ml
^aS_mix ratio for Labrasol+Tween 80: Transcutol-P is 3 (1:1):1
^bChitosan concentration in QMME is 0.5% w/v

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