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Table 2 Composition and physicochemical characterization of quetiapine loaded microemulsion (QME) and mucoadhesive microemulsion (QMME) (data represents mean ± SD, n = 3)

From: Comparative evaluation of intranasally delivered quetiapine loaded mucoadhesive microemulsion and polymeric nanoparticles for brain targeting: pharmacokinetic and gamma scintigraphy studies

Formulations* Oil Smixa (% w/w) Water Drug loading (%) Globule size (nm) PDI Zeta potential (mV) pH Viscosity (cP)
QME 6 44 50 96.18 ± 1.23 29.75 ± 0.99 0.221 ± 0.01 2.77 ± 0.51 5.94 ± 0.08 17.5 ± 0.69
QMMEb 6 44 50 95.43 ± 0.92 35.31 ± 1.71 0.249 ± 0.03 20.29 ± 1.23 4.98 ± 0.12 38.5 ± 1.26
  1. *Concentration of quetiapine fumarate in each formulation is 23 mg/ml
  2. aSmix ratio for Labrasol+Tween 80: Transcutol-P is 3 (1:1):1
  3. bChitosan concentration in QMME is 0.5% w/v