Development and validation of a simple and rapid ICP-OES method for quantification of elemental impurities in voriconazole drug substance

Future Journal of Pharmaceutical Sciences

Table 10 Method precision and ruggedness results

Results for method precision and ruggedness
Sample preparations	Method precision	Ruggedness	Method precision	Ruggedness	Method precision	Ruggedness
Sample preparations	Lead (μg/g)		Palladium (μg/g)		Zinc (μg/g)
1	0.29	0.29	0.47	0.51	18.92	16.50
2	0.30	0.30	0.50	0.51	18.62	16.69
3	0.31	0.29	0.48	0.48	18.40	16.37
4	0.29	0.30	0.47	0.50	17.74	16.16
5	0.29	0.32	0.47	0.49	17.70	16.56
6	0.29	0.30	0.46	0.47	17.67	16.43
%RSD	2.8	3.7	2.9	3.3	3.0	1.1
Overall % RSD	3.2		3.6		5.7