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Table 5 Polymer blends in selected marketed products

From: Applications of polymer blends in drug delivery

Commercial product/API/dosage form/manufacturing proccess

Polymeric/non-polymeric excipients (manufacturing process)



Glumetza®/Metformin HCl 500-mg/tablets/not disclosed (patent examples list direct compression)

Hypromellose, microcrystalline cellulose, polyethylene oxide/coloring, magnesium stearate

Assertio Therapeutics

[2, 14]

Noxafil®/posaconazole 100 mg/gastro-resistant tablets/HME

Tablet core: hypromellose acetate succinate, cellulose microcrystalline, hydroxypropylcellulose, croscarmellose sodium/silica dental type, magnesium stearate

Film coating: polyvinyl alcohol, macrogol 3350/titanium dioxide, talc, iron oxide yellow


[15, 16]

Isoptrin® SR/verapamil HCl 120, 180, 240-mg/sustained-release tablets/not disclosed

Tablet core: alginate, microcrystalline cellulose

polyvinyl pyrrolidone/magnesium stearate

Film coating: hypromellose, polyethylene glycol/talc, titanium dioxide, color additives



Nucynta® ER/(tapentadol) 50, 100, 150, 200, 250-mg/extended-release tablets/HME

Tablet core: hypromellose, polyethylene glycol, polyethylene oxide/alpha-tocopherol (vitamin E)

Film coating: polyvinyl alcohol, polyethylene glycol/talc, titanium dioxide, coloring agents and printing inks

Collegium Pharmaceutical


Envarsus XR®/tacrolimus 0.75 mg, 1 mg, 4 mg/extended-release tablets/melt drug-polymer solution coated onto carrier

Polyethylene glycol, poloxamer, hypromellose/lactose monohydrate , magnesium stearate, tartaric acid, butylated hydroxytoluene, and dimethicone


[21, 22]

Sympazan® oral film/clobazam/5, 10, 20 mg/orally dissolving film strips/wet casting (HME listed as an alternative)

Hypromellose, polyethylene oxide/artificial cooling flavor, citric acid, glycerol monooleate, maltitol, natural and artificial bitter masker, natural raspberry type flavor, purified water, sodium phosphate dibasic, and sucralose

Aquestive Therapeutics


Belbuca®/buprenorphine 75, 150, 300, 450, 600, 750, 900 mcg/buccal film/wet casting

Mucoadhesive layer: carmellose sodium, hydroxyethyl cellulose, hydroxypropyl cellulose, polycarbophil/propylene glycol, sodium benzoate, methylparaben, propylparaben, iron oxide, anhydrous citric acid, vitamin E acetate, monobasic sodium phosphate (anhydrous), sodium hydroxide

Backing layer: hydroxypropyl cellulose and hydroxyethyl cellulose and non-polymeric components

BioDelivery Sciences

[26, 27]

Cod liver oil high strength/omega 3 fish oils/capsules/liquid-gel mixing

Capsule shell: modified maize starch, carrageenan/glycerol, sodium carbonate

Seven Seas


Genteal® tears severe lubricant eye gel/HPMC/gel/liquid mixing

Hypromellose, carbopol 980/phosphoric acid, purified water, sodium hydroxide, sodium perborate, and sorbitol



DurystaTM/bimatoprost 10 mcg/biodegradable implant/HME

Poly(d,l-lactide), poly (D,L-lactide-co-glycolide), poly (D,L-lactide) acid end, polyethylene glycol 3350



Sinuva™/1350 mcg of mometasone furoate/sinus implant/drug-polymer coating of extrudate

Poly(d,l-lactide-co-glycolide), polyethylene glycol

Intersect ENT


XHANCE®/93 mcg of fluticasone propionate in each 106-mg spray/nasal spray/liquid mixing

Microcrystalline cellulose, carboxymethylcellulose sodium/dextrose, benzalkonium chloride, polysorbate 80, edetate disodium dihydrate, purified water



Neupro®/rotigotine 2 mg/transdermal patch/film casting

Self adhesive matrix layer: poly(dimethylsiloxane, trimethylsilyl silicate)-copolymerisate, povidone K90/sodium metabisulphite, ascorbyl palmitate, DL-α-tocopherol (NB: product also has a backing layer and release liner)

UCB Pharma Limited

[33, 34]

  1. Abbreviations: API active pharmaceutical ingredient, HME hot melt extrusion, HPMC hypromellose