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Table 5 Polymer blends in selected marketed products

From: Applications of polymer blends in drug delivery

Commercial product/API/dosage form/manufacturing proccess Polymeric/non-polymeric excipients (manufacturing process) Company Ref.
Glumetza®/Metformin HCl 500-mg/tablets/not disclosed (patent examples list direct compression) Hypromellose, microcrystalline cellulose, polyethylene oxide/coloring, magnesium stearate Assertio Therapeutics [2, 14]
Noxafil®/posaconazole 100 mg/gastro-resistant tablets/HME Tablet core: hypromellose acetate succinate, cellulose microcrystalline, hydroxypropylcellulose, croscarmellose sodium/silica dental type, magnesium stearate
Film coating: polyvinyl alcohol, macrogol 3350/titanium dioxide, talc, iron oxide yellow
Merck [15, 16]
Isoptrin® SR/verapamil HCl 120, 180, 240-mg/sustained-release tablets/not disclosed Tablet core: alginate, microcrystalline cellulose
polyvinyl pyrrolidone/magnesium stearate
Film coating: hypromellose, polyethylene glycol/talc, titanium dioxide, color additives
Ranbaxy [17,18,19]
Nucynta® ER/(tapentadol) 50, 100, 150, 200, 250-mg/extended-release tablets/HME Tablet core: hypromellose, polyethylene glycol, polyethylene oxide/alpha-tocopherol (vitamin E)
Film coating: polyvinyl alcohol, polyethylene glycol/talc, titanium dioxide, coloring agents and printing inks
Collegium Pharmaceutical [20]
Envarsus XR®/tacrolimus 0.75 mg, 1 mg, 4 mg/extended-release tablets/melt drug-polymer solution coated onto carrier Polyethylene glycol, poloxamer, hypromellose/lactose monohydrate , magnesium stearate, tartaric acid, butylated hydroxytoluene, and dimethicone Veloxis [21, 22]
Sympazan® oral film/clobazam/5, 10, 20 mg/orally dissolving film strips/wet casting (HME listed as an alternative) Hypromellose, polyethylene oxide/artificial cooling flavor, citric acid, glycerol monooleate, maltitol, natural and artificial bitter masker, natural raspberry type flavor, purified water, sodium phosphate dibasic, and sucralose Aquestive Therapeutics [23,24,25]
Belbuca®/buprenorphine 75, 150, 300, 450, 600, 750, 900 mcg/buccal film/wet casting Mucoadhesive layer: carmellose sodium, hydroxyethyl cellulose, hydroxypropyl cellulose, polycarbophil/propylene glycol, sodium benzoate, methylparaben, propylparaben, iron oxide, anhydrous citric acid, vitamin E acetate, monobasic sodium phosphate (anhydrous), sodium hydroxide
Backing layer: hydroxypropyl cellulose and hydroxyethyl cellulose and non-polymeric components
BioDelivery Sciences [26, 27]
Cod liver oil high strength/omega 3 fish oils/capsules/liquid-gel mixing Capsule shell: modified maize starch, carrageenan/glycerol, sodium carbonate Seven Seas [28]
Genteal® tears severe lubricant eye gel/HPMC/gel/liquid mixing Hypromellose, carbopol 980/phosphoric acid, purified water, sodium hydroxide, sodium perborate, and sorbitol Alcon [29]
DurystaTM/bimatoprost 10 mcg/biodegradable implant/HME Poly(d,l-lactide), poly (D,L-lactide-co-glycolide), poly (D,L-lactide) acid end, polyethylene glycol 3350 Allergan [30]
Sinuva™/1350 mcg of mometasone furoate/sinus implant/drug-polymer coating of extrudate Poly(d,l-lactide-co-glycolide), polyethylene glycol Intersect ENT [31]
XHANCE®/93 mcg of fluticasone propionate in each 106-mg spray/nasal spray/liquid mixing Microcrystalline cellulose, carboxymethylcellulose sodium/dextrose, benzalkonium chloride, polysorbate 80, edetate disodium dihydrate, purified water OptiNose [32]
Neupro®/rotigotine 2 mg/transdermal patch/film casting Self adhesive matrix layer: poly(dimethylsiloxane, trimethylsilyl silicate)-copolymerisate, povidone K90/sodium metabisulphite, ascorbyl palmitate, DL-α-tocopherol (NB: product also has a backing layer and release liner) UCB Pharma Limited [33, 34]
  1. Abbreviations: API active pharmaceutical ingredient, HME hot melt extrusion, HPMC hypromellose