Commercial product/API/dosage form/manufacturing proccess | Polymeric/non-polymeric excipients (manufacturing process) | Company | Ref. |
---|---|---|---|
Glumetza®/Metformin HCl 500-mg/tablets/not disclosed (patent examples list direct compression) | Hypromellose, microcrystalline cellulose, polyethylene oxide/coloring, magnesium stearate | Assertio Therapeutics | |
Noxafil®/posaconazole 100 mg/gastro-resistant tablets/HME | Tablet core: hypromellose acetate succinate, cellulose microcrystalline, hydroxypropylcellulose, croscarmellose sodium/silica dental type, magnesium stearate Film coating: polyvinyl alcohol, macrogol 3350/titanium dioxide, talc, iron oxide yellow | Merck | |
Isoptrin® SR/verapamil HCl 120, 180, 240-mg/sustained-release tablets/not disclosed | Tablet core: alginate, microcrystalline cellulose polyvinyl pyrrolidone/magnesium stearate Film coating: hypromellose, polyethylene glycol/talc, titanium dioxide, color additives | Ranbaxy | |
Nucynta® ER/(tapentadol) 50, 100, 150, 200, 250-mg/extended-release tablets/HME | Tablet core: hypromellose, polyethylene glycol, polyethylene oxide/alpha-tocopherol (vitamin E) Film coating: polyvinyl alcohol, polyethylene glycol/talc, titanium dioxide, coloring agents and printing inks | Collegium Pharmaceutical | [20] |
Envarsus XR®/tacrolimus 0.75 mg, 1 mg, 4 mg/extended-release tablets/melt drug-polymer solution coated onto carrier | Polyethylene glycol, poloxamer, hypromellose/lactose monohydrate , magnesium stearate, tartaric acid, butylated hydroxytoluene, and dimethicone | Veloxis | |
Sympazan® oral film/clobazam/5, 10, 20 mg/orally dissolving film strips/wet casting (HME listed as an alternative) | Hypromellose, polyethylene oxide/artificial cooling flavor, citric acid, glycerol monooleate, maltitol, natural and artificial bitter masker, natural raspberry type flavor, purified water, sodium phosphate dibasic, and sucralose | Aquestive Therapeutics | |
Belbuca®/buprenorphine 75, 150, 300, 450, 600, 750, 900 mcg/buccal film/wet casting | Mucoadhesive layer: carmellose sodium, hydroxyethyl cellulose, hydroxypropyl cellulose, polycarbophil/propylene glycol, sodium benzoate, methylparaben, propylparaben, iron oxide, anhydrous citric acid, vitamin E acetate, monobasic sodium phosphate (anhydrous), sodium hydroxide Backing layer: hydroxypropyl cellulose and hydroxyethyl cellulose and non-polymeric components | BioDelivery Sciences | |
Cod liver oil high strength/omega 3 fish oils/capsules/liquid-gel mixing | Capsule shell: modified maize starch, carrageenan/glycerol, sodium carbonate | Seven Seas | [28] |
Genteal® tears severe lubricant eye gel/HPMC/gel/liquid mixing | Hypromellose, carbopol 980/phosphoric acid, purified water, sodium hydroxide, sodium perborate, and sorbitol | Alcon | [29] |
DurystaTM/bimatoprost 10 mcg/biodegradable implant/HME | Poly(d,l-lactide), poly (D,L-lactide-co-glycolide), poly (D,L-lactide) acid end, polyethylene glycol 3350 | Allergan | [30] |
Sinuvaâ„¢/1350 mcg of mometasone furoate/sinus implant/drug-polymer coating of extrudate | Poly(d,l-lactide-co-glycolide), polyethylene glycol | Intersect ENT | [31] |
XHANCE®/93 mcg of fluticasone propionate in each 106-mg spray/nasal spray/liquid mixing | Microcrystalline cellulose, carboxymethylcellulose sodium/dextrose, benzalkonium chloride, polysorbate 80, edetate disodium dihydrate, purified water | OptiNose | [32] |
Neupro®/rotigotine 2 mg/transdermal patch/film casting | Self adhesive matrix layer: poly(dimethylsiloxane, trimethylsilyl silicate)-copolymerisate, povidone K90/sodium metabisulphite, ascorbyl palmitate, DL-α-tocopherol (NB: product also has a backing layer and release liner) | UCB Pharma Limited |