Fig. 5

In vivo antitumor activity of MEUP tested at two dose levels (200 mg/kg and 400 mg/kg). a Immunosuppression: difference in WBC and lymphocyte counts of C57bl/6 mice on day 0 and day 7. Results are represented as mean ±SD (n = 24). * represents significant differences in cell counts on day 0 and day 7 in immunosuppressed mice. b Reduction in tumor volume of mice in different groups. Significant reduction in tumor volumes was observed in positive (cisplatin) and test groups (T1 and T2). Results are represented as mean ± SD. The asterisk represents a significant difference in tumor volume between DC and treatment groups. c Representative images of tumor bearing mice treated with cisplatin and MEUP. Tumor position in mice is shown by arrows. d Tumor weights of mice treated with cisplatin and MEUP taken at the end of study. Results are represented as mean ± SD. The asterisk represents significant difference in tumor weights between DC and treatment groups. (P < 0.05)