Toxicological evaluations of betulinic acid and ursolic acid; common constituents of Houttuynia cordata used as an anthelmintic by the Naga tribes in North-east India

Mishra, Vijaya; Soren, Amar Deep; Yadav, Arun Kumar

doi:10.1186/s43094-020-00173-4

Future Journal of Pharmaceutical Sciences

Table 1 Effect of sub-acute oral administration of BA and APAP on body weight (g) of Wistar rats (n = 5/sex)

From: Toxicological evaluations of betulinic acid and ursolic acid; common constituents of Houttuynia cordata used as an anthelmintic by the Naga tribes in North-east India

Week	G-I Control	G-II BA 1 mg/kg	G-III BA 5 mg/kg	G-IV BA 10 mg/kg	G-V APAP 50 mg/kg	Satellite groups
Week	G-I Control	G-II BA 1 mg/kg	G-III BA 5 mg/kg	G-IV BA 10 mg/kg	G-V APAP 50 mg/kg	G-VI Control	G-VII BA 10 mg/kg	G-VIII APAP 50 mg/kg
Female
W0	196.4 ± 3.22	194.2 ± 2.65	193.2 ± 2.24	194.6 ± 2.54	193.6 ± 1.13	195.6 ± 2.83	198.6 ± 1.43	200.8 ± 1.24
W1	196.2 ± 4.21	196.7 ± 2.48	192.2 ± 2.80	197.8 ± 0.80	188.5 ± 0.44	200.6 ± 1.20	195.3 ± 0.63	202.2 ± 1.18
W2	200.2 ± 3.39	194.8 ± 2.47	193.6 ± 1.66	196.2 ± 0.58	186.2 ± 0.37	203.4 ± 1.28	195.2 ± 0.58	200.4 ± 1.20
W3	203.2 ± 3.11	193.8 ± 1.15^a	191.2 ± 1.70^a	195.8 ± 0.66^a	182.2 ± 0.37	205.4 ± 1.28	194.4. ± 0.50	198.4 ± -0.87^c
W4	204.8 ± 3.07	192.8 ± 2.47^a	190.6 ± 1.86^a	193.8 ± 0.66^a	178.6 ± 0.31^a	207.2 ± 1.34	192.2 ± 0.58^c	196.8 ± 0.58
W5						209.1 ± 0.37	195.5 ± 0.70	199.4 ± 0.50
W6						210.2 ± 1.31	197.4 ± 0.81	202.6 ± 0.42^c
Male
W0	201.8 ± 0.86	204.8 ± 2.61	207.2 ± 0.89	205.2 ± 0.44	203.2 ± 0.48	197.6 ± 2.81	200.4 ± 0.30	203.2 ± 0.70
W1	204.2 ± 0.63	205.4 ± 2.73	207.6 ± 0.81	204.2 ± 0.37	200.6 ± 0.24	200.4 ± 3.92	198.4 ± 1.50	203.8 ± 1.73
W2	205.6 ± 0.40	204.2 ± 0.91	205.8 ± 0.58	202.8 ± 0.45	195.6 ± 0.24	203.6 ± 3.74	196.6 ± 1.50^c	201.6 ± 2.81
W3	207.6 ± 1.50	204.8 ± 0.96	204.5 ± 0.54	200.2 ± 0.37^a	189.6 ± 0.24^a	205.8 ± 1.58	197.4 ± 1.25^c	199.2 ± 0.86
W4	209.2 ± 2.66	202.8 ± 0.96^a	202.8 ± 0.66^a	198.6 ± 0.50^b	185.4 ± 0.24^a	208.2 ± 1.54	196.2 ± 0.37^c	197.2 ± 2.73
W5						210.6 ± 2.81	198.8 ± 0.48	199.6 ± 0.74
W6						212.2 ± 2.66	200.4 ± 2.81	202.2 ± 2.54

Data are expressed as mean ± SEM; treatment: G-II to G-IV = 4 weeks, G-V to G-VI = 6 weeks; W0: week before treatment; W1−W6: weeks post-treatment
^ap < 0.05, ^bp < 0.01, vs control; ^cp < 0.05, vs satellite control, one-way ANOVA

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