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Table 2 Effects of sub-acute oral administration of UA and APAP on body weight (g) of Wistar rats (n = 5/sex)

From: Toxicological evaluations of betulinic acid and ursolic acid; common constituents of Houttuynia cordata used as an anthelmintic by the Naga tribes in North-east India

Week

G-I

Control

G-II

UA

1 mg/kg

G-III

UA

5 mg/kg

G-IV

UA

10 mg/kg

G-V

APAP

50 mg/kg

Satellite groups

G-VI

Control

G-VII

UA

10 mg/kg

G-VIII

APAP

50 mg/kg

Female

 W0

196.2 ± 2.88

198.2 ± 2.97

197.4 ± 1.77

197.2 ± 3.27

199.6 ± 3.51

197.2 ± 3.11

197.2 ± 1.72

195.8 ± 3.14

 W1

200.6 ± 0.60

200.2 ± 1.57

198.8 ± 1.56

197.6 ± 1.72

197.2 ± 1.24

202.2 ± 0.66

199.6 ± 1.43

197.7 ± 1.70

 W2

203.4 ± 0.50

199.4 ± 1.50

198.0 ± 1.36

196.2 ± 1.52

195.8 ± 1.11

204.2 ± 0.70

197.8 ± 1.28

196.2 ± 1.70

 W3

205.4 ± 0.50

199.8 ± 1.31

197.2 ± 1.24a

196.2 ± 1.50a

192.6 ± 1.02a

205.0 ± 0.70

193.4 ± 0.92

192.2 ± 1.70

 W4

207.2 ± 0.31

199.5 ± 1.14

196.8 ± 1.01a

194.4 ± 1.20a

192.4 ± 0.92

206.6 ± 0.50

192.6 ± 1.07

190.6 ± 1.50

 W5

     

207.6 ± 0.50

193.0 ± 0.89

190.4 ± 1.56

 W6

     

209.2 ± 0.66

194.8 ± 0.98

197.2 ± 1.78

Male

 W0

199.8 ± 2.81

200.2 ± 0.82

201.4 ± 1.07

201.8 ± 1.35

202.2 ± 1.59

202.6 ± 0.70

201.6 ± 1.26

202.6 ± 1.32

 W1

205.6 ± 1.56

200.2 ± 0.86

200.8 ± 1.06

200.2 ± 0.83

201.2 ± 1.77

203.4 ± 0.50

200.3 ± 1.22

201.2 ± 1.22

 W2

209.4 ± 0.08

199.2 ± 0.73

199.8 ± 1.06

199.5 ± 0.83

199.8 ± 1.56

204.4 ± 0.50

199.4 ± 0.86

198.6 ± 1.07

 W3

210.8 ± 1.49

199.4 ± 0.54

198.4 ± 1.04

198.8 ± 0.66

198.4 ± 1.43a

205.4 ± 0.50

198.2 ± 0.86

197.6 ± 1.07

 W4

212.8 ± 1.68

198.2 ± 0.58

197.5 ± 1.06a

196.2 ± 0.54a

197.8 ± 1.24a

206.6 ± 0.50

197.4 ± 1.04

195.8 ± 1.31

 W5

     

207.6 ± 0.50

198.2 ± 1.11

198.4 ± 1.14

 W6

     

209.2 ± 0.37

199.8 ± 1.06

201.8 ± 1.25

  1. Data are expressed as mean ± SEM; treatment: G-II to G-IV = 4 weeks, G-V to G-VI = 6 weeks; W0: week before treatment; W1−W6: weeks post-treatment
  2. ap < 0.05, vs control; bp < 0.05 vs satellite control, one-way ANOVA