Toxicological evaluations of betulinic acid and ursolic acid; common constituents of Houttuynia cordata used as an anthelmintic by the Naga tribes in North-east India

Mishra, Vijaya; Soren, Amar Deep; Yadav, Arun Kumar

doi:10.1186/s43094-020-00173-4

Future Journal of Pharmaceutical Sciences

Table 4 Effects of sub-acute oral administration of UA and APAP on relative organ ROW of Wistar rats (n = 5/sex)

From: Toxicological evaluations of betulinic acid and ursolic acid; common constituents of Houttuynia cordata used as an anthelmintic by the Naga tribes in North-east India

Organ	G-I Control	G-II UA 1 mg/kg	G-III UA 5 mg/kg	G-IV UA 10 mg/kg	G-V APAP 50 mg/kg	Satellite groups
Organ	G-I Control	G-II UA 1 mg/kg	G-III UA 5 mg/kg	G-IV UA 10 mg/kg	G-V APAP 50 mg/kg	G-VI Control	G-VII UA 10 mg/kg	G-VIII APAP 50 mg/kg
Female
Heart	0.57 ± 0.01	0.67 ± 0.05	0.68 ± 0.06	0.65 ± 0.08	0.62 ± 0.06	0.59 ± 0.13	0.62 ± 0.07	0.77 ± 0.03
Liver	5.81 ± 0.21	5.66 ± 0.69	5.28 ± 0.52	4.93 ± 0.55^a	6.82 ± 1.05^b	5.76 ± 0.38	5.82 ± 0.55	5.55 ± 0.31
Brain	1.09 ± 0.02	1.02 ± 0.02	1.02 ± 0.02	1.02 ± 0.01	0.99 ± 0.01	0.99 ± 0.00	0.99 ± 0.00	0.99 ± 0.00
Spleen	0.49 ± 0.03	0.42 ± 0.05	0.45 ± 0.06	0.35 ± 0.05^a	0.71 ± 0.05^a	0.46 ± 0.05	0.39 ± 0.08	0.43 ± 0.07
Adrenal	0.03 ± 0.00	0.03 ± 0.00	0.02 ± 0.00	0.02 ± 0.00	0.02 ± 0.00	0.03 ± 0.00	0.03 ± 0.00	0.03 ± 0.00
Kidney (L)	0.58 ± 0.10	0.71 ± 0.02	0.63 ± 0.04	0.77 ± 0.04	0.73 ± 0.09	0.57 ± 0.06	0.55 ± 0.09	0.57 ± 0.02
Kidney (R)	0.58 ± 0.12	0.73 ± 0.01	0.73 ± 0.04	0.72 ± 0.08	0.71 ± 0.12	0.66 ± 0.03	0.73 ± 0.04	0.57 ± 0.01
Ovary	0.06 ± 0.00	0.06 ± 0.00	0.06 ± 0.01	0.06 ± 0.00	0.06 ± 0.00	0.06 ± 0.00	0.06 ± 0.00	0.06 ± 0.00
Male
Heart	0.61 ± 0.03	0.65 ± 0.09	0.69 ± 0.10	0.72 ± 0.09	0.62 ± 0.02	0.62 ± 0.09	0.62 ± 0.08	0.77 ± 0.04
Liver	6.46 ± 0.15	6.55 ± 0.95	6.21 ± 0.18	5.76 ± 0.50^a	7.13 ± 1.20^c	6.19 ± 1.09	6.51 ± 0.80	7.23 ± 0.57
Brain	1.28 ± 0.10	1.03 ± 0.01	1.05 ± 0.02	1.01 ± 0.01	1.01 ± 0.01	1.01 ± 0.02	1.02 ± 0.01	1.01 ± 0.01
Spleen	0.44 ± 0.03	0.48 ± 0.06	0.34 ± 0.03	0.32 ± 0.04^a	0.76 ± 0.12^a	0.49 ± 0.07	0.48 ± 0.07	0.53 ± 0.08
Adrenal	0.03 ± 0.00	0.03 ± 0.00	0.03 ± 0.00	0.02 ± 0.00	0.02 ± 0.00	0.02 ± 0.00	0.02 ± 0.00	0.03 ± 0.00
Kidney (L)	0.60 ± 0.14	0.72 ± 0.01	0.74 ± 0.03	0.70 ± 0.02	0.77 ± 0.02	0.66 ± 0.09	0.63 ± 0.04	0.55 ± 0.09
Kidney (R)	0.56 ± 0.10	0.78 ± 0.01	0.72 ± 0.03	0.71 ± 0.09	0.76 ± 0.14	0.63 ± 0.07	0.72 ± 0.03	0.64 ± 0.04
Testis (L)	0.71 ± 0.04	0.76 ± 0.05	0.69 ± 0.03	0.77 ± 0.15	0.86 ± 0.06	0.75 ± 0.02	0.69 ± 0.03	0.73 ± 0.03
Testis (R)	0.74 ± 0.03	0.71 ± 0.05	0.74 ± 0.03	0.67 ± 0.11	0.66 ± 0.15	0.72 ± 0.07	0.74 ± 0.03	0.78 ± 0.01

Data are expressed as mean ± SEM; treatment: G-II to G-IV = 4 weeks, G-V to G-VI = 6 weeks
^ap < 0.05 vs control; one-way ANOVA. L—left, R—right

Back to article page