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Table 5 Effects of sub-acute oral administration of BA and APAP on selected biochemical parameters of Wistar rats (n = 5/sex)

From: Toxicological evaluations of betulinic acid and ursolic acid; common constituents of Houttuynia cordata used as an anthelmintic by the Naga tribes in North-east India

Parameters

G-I

Control

G-II

BA

1 mg/kg

G-III

BA

5 mg/kg

G-IV

BA

10 mg/kg

G-V

APAP

50 mg/kg

Satellite groups

G-VI

Control

G-VII

BA

10 mg/kg

G-VIII

APAP

50 mg/kg

Female

 SGOT (U/L)

84.11 ± 5.1

92.06 ± 3.3

108.53 ± 7.8a

148.8 ± 9.6b

195.05 ± 3.7a

88.58 ± 6.8

81.97 ± 5.7

113.38 ± 9.1

 SGPT (U/L)

80.55 ± 6.3

81.45 ± 9.9

81.49 ± 12.6

84.12 ± 1.4

115.49 ± 12.3a

84.19 ± 9.4

81.56 ± 7.3

67.77 ± 8.4

 ALP (U/L)

86.67 ± 1.3

107.07 ± 3.6a

110.0 ± 4.9b

308.12 ± 8.3a

194.40 ± 5.6a

92.09 ± 6.4

92.53 ± 7.0

139.7 ± 13.8

 Bili (mg/dl)

0.76 ± 0.06

0.69 ± 0.08b

0.69 ± 0.01b

0.68 ± 0.0b

0.67 ± 0.15b

0.72 ± 0.06

0.74 ± 0.04

0.85 ± 0.06

 Alb (gm/dl)

3.76 ± 0.08

4.01 ± 0.40

4.90 ± 0.22a

4.90 ± 0.35a

4.09 ± 0.72a

4.23 ± 0.32

4.26 ± 0.40

3.83 ± 0.57

 Urea (mg/dl)

21.55 ± 0.9

24.01 ± 0.5

24.89 ± 1.5

39.80 ± 0.3a

33.40 ± 4.5a

28.19 ± 0.9

25.93 ± 1.1

28.36 ± 1.1

 Crt (mg/dl)

0.60 ± 0.11

0.77 ± 0.03

0.73 ± 0.04

0.76 ± 0.02a

0.58 ± 0.08a

0.64 ± 0.02

0.67 ± 0.06

0.56 ± 0.04

Male

 SGOT (U/L)

71.02 ± 8.09

93.63 ± 5.05

107.64 ± 4.3a

155.98 ± 7.7a

200.29 ± 7.43a

94.32 ± 7.84

83.37 ± 5.79

81.05 ± 8.13

 SGPT (U/L)

62.10 ± 0.70

69.94 ± 8.16

78.37 ± 14.3a

78.72 ± 0.51a

124.32 ± 13.9a

73.87 ± 13.8

75.69 ± 11.0

77.40 ± 4.61

 ALP (U/L)

88.72 ± 1.55

105.94 ± 2.2a

103.15 ± 4.9a

321.8 ± 7.8b

176.40 ± 2.73a

98.27 ± 5.15

90.17 ± 7.42

104.1 ± 17.7

 Bili (mg/dl)

0.82 ± 0.06

0.78 ± 0.08a

0.76 ± 0.0a

0.68 ± 0.0b

0.42 ± 0.19a

0.80 ± 0.07

0.73 ± 0.05

0.85 ± 0.04

 Alb (gm/dl)

4.02 ± 0.03

4.18 ± 0.43

4.36 ± 0.25

4.88 ± 0.01a

5.84 ± 0.44a

4.43 ± 0.39

4.20 ± 0.42

5.02 ± 0.70

 Urea (mg/dl)

24.05 ± 0.16

23.29 ± 0.43

25.77 ± 2.10

40.21 ± 0.28a

32.17 ± 4.57a

20.55 ± 1.95

19.00 ± 4.02

21.31 ± 3.76

 Crt (mg/dl)

0.62 ± 0.10

0.78 ± 0.04

0.76 ± 0.03

0.80 ± 0.08a

0.78 ± 0.02a

0.68 ± 0.03

0.67 ± 0.04

0.64 ± 0.07

  1. Data are expressed as mean ± SEM; treatment: G-II to G-IV = 4 weeks, G-V to G-VI = 6 weeks
  2. ap < 0.05, bp < 0.01 vs control; one-way ANOVA