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Table 6 Effects of sub-acute oral administration of UA and APAP on selected biochemical parameters of Wistar rats (n = 5/sex)

From: Toxicological evaluations of betulinic acid and ursolic acid; common constituents of Houttuynia cordata used as an anthelmintic by the Naga tribes in North-east India

Parameters

G-I

Control

G-II

UA

1 mg/kg

G-III

UA

5 mg/kg

G-IV

UA

10 mg/kg

G-V

APAP

50 mg/kg

Satellite groups

G-VI

Control

G-VII

UA

10 mg/kg

G-VIII

APAP

50 mg/kg

Female

 SGOT (U/L)

68.77 ± 9.03

96.60 ± 4.2a

111.0 ± 8.3b

165.7 ± 0.3b

182.19 ± 4.4a

91.59 ± 7.4

73.68 ± 5.2

101.04 ± 2.9

 SGPT (U/L)

61.32 ± 6.17

56.80 ± 10.6

57.7 ± 14.25

62.68 ± 2.40

111.40 ± 11.5a

90.67 ± 10.0

83.41 ± 8.3

68.23 ± 7.52

 ALP (U/L)

85.48 ± 5.40

115.00 ± 6.2a

117.7 ± 8.8b

184.0 ± 2.7b

193.60 ± 6.4c

99.64 ± 7.52

92.04 ± 6.4

129.57 ± 8.80

 Bili (mg/dl)

0.71 ± 0.07

0.64 ± 0.05

0.57 ± 0.05

0.46 ± 0.00

0.78 ± 0.04

0.79 ± 0.04

0.76 ± 0.05

0.82 ± 0.06

 Alb (gm/dl)

3.70 ± 0.45

3.95 ± 0.35

4.14 ± 0.34

3.82 ± 0.11

4.24 ± 0.68

4.00 ± 0.30

4.31 ± 0.34

3.83 ± 0.40

 Urea (mg/dl)

22.51 ± 1.81

23.24 ± 1.06

23.73 ± 2.16

20.22 ± 0.31

28.13 ± 5.35

19.82 ± 0.99

17.28 ± 0.39

19.25 ± 1.02

 Crt (mg/dl)

0.53 ± 0.14

0.74 ± 0.02

0.72 ± 0.04

0.77 ± 0.01

0.72 ± 0.10

0.65 ± 0.06

0.76 ± 0.04

0.64 ± 0.03

Male

 SGOT (U/L)

84.83 ± 6.60

104.60 ± 3.7

108.36 ± 4.1

197.2 ± 0.8b

190.13 ± 4.28a

99.19 ± 8.45

92.38 ± 7.58

118.18 ± 4.34

 SGPT (U/L)

62.31 ± 11.4

61.60 ± 8.35

60.24 ± 10.7

60.04 ± 1.47

121.09 ± 15.8a

84.06 ± 12.9

75.7 ± 11.09

76.08 ± 2.47

 ALP (U/L)

73.91 ± 2.08

103.60 ± 4.9a

157.0 ± 7.4b

209.9 ± 1.9b

182.80 ± 7.2a

103.96 ± 5.6

106.38 ± 7.5c

102.74 ± 17.2

 Bili (mg/dl)

0.75 ± 0.07

0.75 ± 0.03

0.71 ± 0.04

0.66 ± 0.01

0.77 ± 0.07

0.87 ± 0.07

0.79 ± 0.05

0.84 ± 0.09

 Alb (gm/dl)

4.05 ± 0.66

4.23 ± 0.32

4.68 ± 0.56

4.09 ± 0.07

5.71 ± 0.36c

4.73 ± 0.36

1.23 ± 0.08

4.81 ± 0.51

 Urea (mg/dl)

21.23 ± 1.07

23.58 ± 0.84

23.52 ± 2.04

22.08 ± 0.23

36.89 ± 4.82c

22.86 ± 2.59

23.52 ± 3.96

21.89 ± 0.95

 Crt (mg/dl)

0.70 ± 0.08

0.75 ± 0.04

0.76 ± 0.03

0.80 ± 0.00

0.81 ± 0.05

0.71 ± 0.03

0.72 ± 0.04

0.73 ± 0.02

  1. Data are expressed as mean ± SEM; treatment: G-II to G-IV = 4 weeks, G-V to G-VI = 6 weeks
  2. ap < 0.05, bp < 0.01 vs control; cp < 0.05 vs satellite control, one-way ANOVA