Sr. No. | Property of MNs | Description |
---|---|---|
1. | Ruggedness | Should be able to resist the insertion force without being featured. |
2. | Penetration | Must be penetrated the drug at the required depth of tissue. |
3. | Dimensions | Length :- 100-900microns; Base width :50-300microns; Tip diameter: 1-50microns |
4. | Margin of safety | =\( \frac{\mathrm{the}\ \mathrm{for}\mathrm{ce}\ \mathrm{required}\ \mathrm{for}\ \mathrm{piercing}\ \mathrm{the}\ \mathrm{SC}}{\mathrm{the}\ \mathrm{for}\mathrm{ce}\ \mathrm{at}\ \mathrm{which}\ \mathrm{MNs}\ \mathrm{broke}} \) |
5. | Effect of the MN length on pain | As the length of the needle increases from (i.e., 500–1500 μm), the pain increases. Also, an increase in the digit of MNs from 5 to 50 resulted in the increases in the pain. |
6. | Transepidermal water loss | Intact animal skin, sing diffusion cell as well as probes that evaluate transepidermal water loss before and after MN application |
7. | Biological safety test | Extract chemicals from MNs by immersing them in physiological saline and apply them on intact human skin. |