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Table 7 MNs approved product for pharmaceutical applications

From: Emerging era of microneedle array for pharmaceutical and biomedical applications: recent advances and toxicological perspectives

Product name

Manufactured by

Types of MNs

Specifications

Applications

Dermaroller®

Dermaroller® Germany, White Lotus

Solid or metal MNs,

Cylindrical roller shape and 0.2 mm to 2.5 mm in length

Use to improve skin texture and treatment of scars and hyperpigmentation.

Dermarollerâ„¢ MS-4

The Dermaroller Series: Anastassakis K

–

Small cylinder, 1 cm length, 2 cm in diameter, 4 circular arrays of needles (total 96 needles)

Use to treatment on facial acne scars

MicroHyala®

CosMED Pharmaceutical Co. Ltd

Dissolvable MNs

Slowly dissolved

Less irritating

Use to wrinkle treatment

h-patch

Valeritas

–

A small adhesive machine like the patch is used

To deliver drugs (insulin) in subcutaneous

Microstructured transdermal system

3 M

Hollow MNs

–

To deliver biologics and other small molecules

Dermarollerâ„¢ MF-8 type

The Dermaroller Series: Anastassakis K

–

A needle length of 1.5 mm (1500 μm)

Used for the treatment of scars

CIT-8 (collagen induction therapy

The Dermaroller Series: Anastassakis K

–

A needle length of 0.5 mm (500 μm)

Used in collagen induction and skin remodeling

LiteClear®

Nanomed skincare

Solid silicon MNs

–

Utilized to treats acne and skin blemishes

Dermarollerâ„¢ C-8 (Cosmetic type)

The Dermaroller Series: Anastassakis K

–

A needle length of 0.13 mm (130 μm), 24 circular arrays of 8 needles each (total 192 needles)

Used to enhance the penetration rate of topical agents

BD Soluvia®

BD, Sanofi Pasteur Europe

Hollow MNs

1.5-mm-long hypodermic needle

Used for Influenza vaccination