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Table 4 Determination of density, floating lag time and floating time of minitablets

From: Formulation and development of floating multiple-unit minitablets of Nimodipine without using a gas-generating agent: in vitro and in vivo characterization

Formulations

*Density (g.cm−3)

*Floating lag time (s)

*Floating duration (h)

*% Floating

F1

0.20 ± 0.01

NF

IF

IF

F2

0.21 ± 0.02

NF

IF

IF

F3

0.24 ± 0.01

235 ± 12

1 ± 0.06

50 ± 2

F4

0.22 ± 0.01

128 ± 7

1.5 ± 0.08

70 ± 3

F5

0.21 ± 0.03

85 ± 3

1 ± 0.04

80 ± 2

F6

0.21 ± 0.01

65 ± 2

6 ± 0.2

90 ± 4

F7

0.20 ± 0.02

56 ± 2

10 ± 0.3

95 ± 2

F8

0.21 ± 0.02

35 ± 3

12 ± 0.4

94 ± 3

F9

0.24 ± 0.02

18 ± 1

14 ± 0.3

100 ± 4

F10

0.23 ± 0.01

15 ± 1

16 ± 0.2

100 ± 3

F11

0.20 ± 0.01

70 ± 2

7 ± 0.2

92 ± 3

F12

0.24 ± 0.02

62 ± 3

9 ± 0.3

96 ± 4

F13

0.20 ± 0.01

38 ± 2

11 ± 0.2

94 ± 3

F14

0.23 ± 0.01

22 ± 1

14 ± 0.4

98 ± 3

F15

0.21 ± 0.03

17 ± 1

16 ± 0.3

100 ± 3

F16

0.22 ± 0.01

NF

IF

IF

F17

0.24 ± 0.01

NF

IF

IF

F18

0.21 ± 0.02

345 ± 11

1.5 ± 0.06

45 ± 2

F19

0.23 ± 0.02

226 ± 8

1.2 ± 0.04

65 ± 3

F20

0.23 ± 0.01

175 ± 9

2 ± 0.01

70 ± 2

  1. *Mean ± SD, n = 6, NF Not Floating, IF Instant floating