Table 7 Determination of in vivo pharmacokinetic parameters
Pharmacokinetic parameters | Nimodipine | OPT. formulation |
|---|---|---|
*K (h− 1) | 0.308 ± 0.012 | 0.054 ± 0.002 |
*Cmax (ng/mL) | 2882.95 ± 123 | 3498.21 ± 152 |
*Tmax(h) | 4 ± 0.1 | 5 ± 0.2 |
*AUC(ng.h/mL) | 21,678.98 ± 78 | 57,438.19 ± 54 |
*AUMC (ng.h2 /mL) | 66,337.67 ± 98 | 445,145.97 ± 58 |
*MRT (h) | 3.06 ± 0.12 | 7.75 ± 0.32 |