Determination of residual solvents in paclitaxel by headspace gas chromatography

Table 17 Results of precision study for all the solvents

Parameter	Percentage RSD
Parameter	Methanol	Ethanol	Acetone	Isopropyl alcohol	Dichloromethane	N-Hexane	Ethyl acetate	Tetrahydrofuran	DIPEA
System precision (standard solution) (peak area)	2.48	3.48	1.25	0.98	0.87	0.85	1.21	0.75	0.64
Precision at LOQ (peak area)	3.51	2.78	2.49	3.48	4.51	3.98	3.48	2.85	2.18
Repeatability (intraday) (content ppm)	0.85	0.57	0.48	0.71	0.73	0.81	0.76	0.81	0.73
Intermediate precision (interday) (content ppm)	0.74	0.97	0.96	0.67	0.71	0.79	0.68	0.71	0.69
Cumulative (intraday and interday) (content ppm)	0.8	0.79	0.74	0.69	0.68	0.73	0.71	0.76	0.71