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Table 19 Robustness study results of methanol

From: Determination of residual solvents in paclitaxel by headspace gas chromatography

Parameter System conditions Percentage RSD for peak area (n = 6) Retention time Plate count Tailing factor
Flow rate (± 0.2 mL/min) 2.3 2.9 5.41 59741 1.3
2.5 2.5 4.93 58451 1.0
2.7 2.2 4.44 57485 1.2
Column oven temperature (± 5 °C) 35 °C 3.0 5.32 59874 1.1
40 °C 2.5 4.93 58451 1.0
45 °C 2.1 4.49 58749 1.2
Vial oven temperature (± 5 °C) 85 °C 2.8 4.91 54758 1.3
90 °C 2.5 4.93 58451 1.0
95 °C 2.6 4.92 58747 1.2