From: Determination of residual solvents in paclitaxel by headspace gas chromatography
Parameter | System conditions | Percentage RSD for peak area (n = 6) | Retention time | Plate count | Tailing factor |
---|---|---|---|---|---|
Flow rate (± 0.2 mL/min) | 2.3 | 1.7 | 7.32 | 79241 | 1.2 |
2.5 | 1.6 | 6.65 | 78485 | 1.1 | |
2.7 | 1.8 | 5.98 | 77142 | 1.2 | |
Column oven temperature (± 5 °C) | 35 °C | 1.4 | 7.29 | 79520 | 1.4 |
40 °C | 1.6 | 6.65 | 78485 | 1.1 | |
45 °C | 1.5 | 6.10 | 80157 | 1.0 | |
Vial oven temperature (± 5 °C) | 85 °C | 1.5 | 6.64 | 76547 | 1.3 |
90 °C | 1.6 | 6.65 | 78485 | 1.1 | |
95 °C | 1.7 | 6.63 | 74215 | 1.2 |