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Table 20 Robustness study results of ethanol

From: Determination of residual solvents in paclitaxel by headspace gas chromatography

Parameter

System conditions

Percentage RSD for peak area (n = 6)

Retention time

Plate count

Tailing factor

Flow rate (± 0.2 mL/min)

2.3

1.7

7.32

79241

1.2

2.5

1.6

6.65

78485

1.1

2.7

1.8

5.98

77142

1.2

Column oven temperature (± 5 °C)

35 °C

1.4

7.29

79520

1.4

40 °C

1.6

6.65

78485

1.1

45 °C

1.5

6.10

80157

1.0

Vial oven temperature (± 5 °C)

85 °C

1.5

6.64

76547

1.3

90 °C

1.6

6.65

78485

1.1

95 °C

1.7

6.63

74215

1.2