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Table 22 Robustness study results of isopropyl alcohol

From: Determination of residual solvents in paclitaxel by headspace gas chromatography

Parameter System conditions Percentage RSD for peak area (n = 6) Retention time Plate count Tailing factor
Flow rate (± 0.2 mL/min) 2.3 2.2 9.07 31248 1.2
2.5 2.0 8.25 32548 1.0
2.7 2.3 7.43 32478 1.3
Column oven temperature (± 5 °C) 35 °C 2.1 9.08 30214 1.2
40 °C 2.0 8.25 32548 1.0
45 °C 2.3 7.45 31067 1.4
Vial oven temperature (± 5 °C) 85 °C 2.1 8.24 30148 1.3
90 °C 2.0 8.25 32548 1.0
95 °C 1.9 8.21 31032 1.1