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Table 25 Robustness study results of ethyl acetate

From: Determination of residual solvents in paclitaxel by headspace gas chromatography

Parameter System conditions Percentage RSD for peak area (n = 6) Retention time Plate count Tailing factor
Flow rate (± 0.2 mL/min) 2.3 1.8 15.17 66574 1.2
2.5 1.7 13.79 65848 1.1
2.7 1.9 12.41 67418 1.1
Column oven temperature (± 5 °C) 35 °C 1.8 15.18 64217 1.3
40 °C 1.7 13.79 65848 1.1
45 °C 1.6 12.43 66412 1.2
Vial oven temperature (± 5 °C) 85 °C 1.7 13.76 64718 1.3
90 °C 1.7 13.79 65848 1.1
95 °C 1.8 13.77 63241 1.2