From: Determination of residual solvents in paclitaxel by headspace gas chromatography
Parameter | System conditions | Percentage RSD for peak area (n = 6) | Retention time | Plate count | Tailing factor |
---|---|---|---|---|---|
Flow rate (± 0.2 mL/min) | 2.3 | 2.9 | 15.53 | 97542 | 1.0 |
2.5 | 2.8 | 14.12 | 97845 | 1.0 | |
2.7 | 2.7 | 12.71 | 97441 | 1.1 | |
Column oven temperature (± 5 °C) | 35 °C | 2.7 | 15.55 | 97635 | 1.3 |
40 °C | 2.8 | 14.12 | 97845 | 1.0 | |
45 °C | 2.7 | 12.74 | 97412 | 1.2 | |
Vial oven temperature (± 5 °C) | 85 °C | 2.7 | 14.11 | 97458 | 1.4 |
90 °C | 2.8 | 14.12 | 97845 | 1.0 | |
95 °C | 2.7 | 14.12 | 96547 | 1.3 |