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Table 26 Robustness study results of tetrahydrofuran

From: Determination of residual solvents in paclitaxel by headspace gas chromatography

Parameter System conditions Percentage RSD for peak area (n = 6) Retention time Plate count Tailing factor
Flow rate (± 0.2 mL/min) 2.3 2.9 15.53 97542 1.0
2.5 2.8 14.12 97845 1.0
2.7 2.7 12.71 97441 1.1
Column oven temperature (± 5 °C) 35 °C 2.7 15.55 97635 1.3
40 °C 2.8 14.12 97845 1.0
45 °C 2.7 12.74 97412 1.2
Vial oven temperature (± 5 °C) 85 °C 2.7 14.11 97458 1.4
90 °C 2.8 14.12 97845 1.0
95 °C 2.7 14.12 96547 1.3