From: Determination of residual solvents in paclitaxel by headspace gas chromatography
Parameter | System conditions | Percentage RSD for peak area (n = 6) | Retention time | Plate count | Tailing factor |
---|---|---|---|---|---|
Flow rate (± 0.2 mL/min) | 2.3 | 3.9 | 19.20 | 93487 | 1.1 |
2.5 | 3.5 | 17.45 | 98751 | 1.2 | |
2.7 | 3.4 | 15.72 | 95249 | 1.1 | |
Column oven temperature (± 5 °C) | 35 °C | 3.1 | 19.23 | 97541 | 1.2 |
40 °C | 3.5 | 17.45 | 98751 | 1.2 | |
45 °C | 3.2 | 15.74 | 96324 | 1.2 | |
Vial oven temperature (± 5 °C) | 85 °C | 3.4 | 17.46 | 97547 | 1.3 |
90 °C | 3.5 | 17.45 | 98751 | 1.2 | |
95 °C | 3.5 | 17.42 | 97452 | 1.2 |