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Table 27 Robustness study results of DIPEA

From: Determination of residual solvents in paclitaxel by headspace gas chromatography

Parameter System conditions Percentage RSD for peak area (n = 6) Retention time Plate count Tailing factor
Flow rate (± 0.2 mL/min) 2.3 3.9 19.20 93487 1.1
2.5 3.5 17.45 98751 1.2
2.7 3.4 15.72 95249 1.1
Column oven temperature (± 5 °C) 35 °C 3.1 19.23 97541 1.2
40 °C 3.5 17.45 98751 1.2
45 °C 3.2 15.74 96324 1.2
Vial oven temperature (± 5 °C) 85 °C 3.4 17.46 97547 1.3
90 °C 3.5 17.45 98751 1.2
95 °C 3.5 17.42 97452 1.2