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Table 4 Aerodynamic assessment of RES-NC-DPI and RES-DPI at a flow rate of 60 L/min (mean ± SD, n = 3)

From: Fabrication and application of dimyristoyl phosphatidylcholine biomaterial-based nanocochleates dry powder inhaler for controlled release resveratrol delivery

Aerodynamic parameters

RES-DPI

RES-NC-DPI

RD (μg)

1470.67 ± 110.22

1797.50 ± 109.65**

ED (μg)

1281.08 ± 132.44

1557.08 ± 120.22

FPD (μg)

780.08 ± 90.22

986.31 ± 82.43**

FPF (%)

53.04 ± 9.08

54.87 ± 9.32

MB (%)

89.74 ± 7.00

91.60 ± 8.33

MMAD (μm)

2.15 ± 0.99

2.30 ± 1.09

GSD (μm)

3.60 ± 1.22

3.16 ± 1.21

D (%)

60.89 ± 8.89

63.34 ± 9.77

EI

11.84 ± 1.09

11.90 ± 1.03

  1. RD recovered dose, ED emitted dose, FPD fine particle dose, FPF fine particle fraction, MB mass balance, D dispersibility, MMAD mass median aerodynamic diameter, GSD geometric standard deviation, and EI effective inhalation index
  2. **p ≤ 0.01 (statistically significant) when compared to the control group RES-DPI