Skip to main content

Table 4 ANOVA for the quadratic model (tensile strength response)

From: Development, optimization and characterization of flurbiprofen matrix transdermal drug delivery system using Box–Behnken statistical design

Source

Sum of squares

df

Mean square

F value

p value

 

Model

2.82

9

0.3136

53.06

< 0.0001

Significant

 A-HPMC K15M:ERL100

1.19

1

1.19

200.75

< 0.0001

 

 B-Di-butyl pthalate

0.0047

1

0.0047

0.7878

0.4042

 

 C-d-limonene

0.0343

1

0.0343

5.81

0.0468

 

AB

0.0648

1

0.0648

10.96

0.0129

 

AC

0.0416

1

0.0416

7.04

0.0328

 

BC

0.1875

1

0.1875

31.72

0.0008

 

A2

1.15

1

1.15

194.09

< 0.0001

 

B2

0.1118

1

0.1118

18.92

0.0034

 

C2

0.0005

1

0.0005

0.0906

0.7722

 

Residual

0.0414

7

0.0059

   

 Lack of Fit

0.0135

3

0.0045

0.6468

0.6247

Not significant

 Pure error

0.0279

4

0.0070

   

Cor total

2.86

16