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Table 5 ANOVA for the quadratic model (steady-state flux response)

From: Development, optimization and characterization of flurbiprofen matrix transdermal drug delivery system using Box–Behnken statistical design

Source

Sum of squares

df

Mean square

F value

p value

 

Model

33488.02

9

3720.89

47.54

< 0.0001

Significant

A-HPMC K15M:ERL100

4783.89

1

4783.89

61.12

0.0001

 

B-Di-butyl pthalate

211.87

1

211.87

2.71

0.1439

 

C-d-limonene

25660.19

1

25660.19

327.86

< 0.0001

 

AB

7.02

1

7.02

0.0897

0.7732

 

AC

847.68

1

847.68

10.83

0.0133

 

BC

5.74

1

5.74

0.0733

0.7944

 

A2

1044.94

1

1044.94

13.35

0.0081

 

B2

543.70

1

543.70

6.95

0.0336

 

C2

200.23

1

200.23

2.56

0.1537

 

Residual

547.86

7

78.27

   

 Lack of Fit

219.20

3

73.07

0.8893

0.5192

Not significant

 Pure error

328.66

4

82.16

   

Cor Total

34035.88

16