Development, optimization and characterization of flurbiprofen matrix transdermal drug delivery system using Box–Behnken statistical design

Future Journal of Pharmaceutical Sciences

Table 7 Model fitting kinetics for in vitro release profile from different transdermal films

Formulation code	Zero-order kinetics (R²)	First-order kinetics (R²)	Higuchi kinetics model (R²)	Hixon–Crowel kinetics model (R²)	Korsmeyer–Peppas kinetics
Formulation code	Zero-order kinetics (R²)	First-order kinetics (R²)	Higuchi kinetics model (R²)	Hixon–Crowel kinetics model (R²)	R²	n
FBPT1	0.982	0.953	0.979	0.985	0.994	0.603
FBPT2	0.992	0.902	0.955	0.960	0.967	0.533
FBPT3	0.998	0.920	0.963	0.964	0.996	0.755
FBPT4	0.996	0.876	0.948	0.940	0.990	0.649
FBPT5	0.998	0.959	0.964	0.981	0.999	0.870
FBPT6	0.997	0.881	0.954	0.948	0.995	0.759
FBPT7	0.997	0.750	0.964	0.894	0.995	0.598
FBPT8	0.996	0.939	0.956	0.969	0.955	0.667
FBPT9	0.996	0.972	0.979	0.991	0.988	0.865
FBPT10	0.996	0.924	0.949	0.966	0.990	0.744
FBPT11	0.994	0.863	0.949	0.931	0.990	0.565
FBPT12	0.998	0.914	0.975	0.966	0.996	0.573
FBPT13	0.997	0.872	0.953	0.940	0.988	0.553
FBPT14	0.995	0.872	0.951	0.935	0.995	0.638
FBPT15	0.995	0.889	0.978	0.961	0.993	0.490
FBPT16	0.999	0.924	0.964	0.967	0.996	0.673
FBPT17	0.998	0.905	0.975	0.962	0.995	0.622