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Table 5 Results of stress degradation studies

From: Multivariate optimization of liquid chromatographic conditions for determination of dapagliflozin and saxagliptin, application to an in vitro dissolution and stability studies

Stress condition

Saxagliptin

Dapagliflozin

% Drug recovered

% Drug decomposed

% Drug recovered

% Drug decomposed

Controlled sample

99.6

 

99.3

 

Acidic (1N HCl, 60 °C, 1 h)

91.2

8.4

84.1

15.2

Alkali (1N NaOH, 60 °C, 1 h)

92.3

7.3

85.6

13.7

Neutral (H2O, 60 °C, 1 h)

97.3

2.3

96.6

2.7

Oxidative (6% v/v H2O2)

80.2

19.4

90.2

9.1

UV light (48 h)

93.7

5.9

94.1

5.2

Thermal (105 °C, 6 h)

89.1

10.5

90.6

8.7