Stress condition | Saxagliptin | Dapagliflozin | ||
---|---|---|---|---|
% Drug recovered | % Drug decomposed | % Drug recovered | % Drug decomposed | |
Controlled sample | 99.6 | 99.3 | ||
Acidic (1N HCl, 60 °C, 1 h) | 91.2 | 8.4 | 84.1 | 15.2 |
Alkali (1N NaOH, 60 °C, 1 h) | 92.3 | 7.3 | 85.6 | 13.7 |
Neutral (H2O, 60 °C, 1 h) | 97.3 | 2.3 | 96.6 | 2.7 |
Oxidative (6% v/v H2O2) | 80.2 | 19.4 | 90.2 | 9.1 |
UV light (48 h) | 93.7 | 5.9 | 94.1 | 5.2 |
Thermal (105 °C, 6 h) | 89.1 | 10.5 | 90.6 | 8.7 |