Type of degradation | Stress condition | Time | Percentage amount of drug (%) | Rf values of degradation product |
---|---|---|---|---|
Base degradation | 0.1 N NaOH, 25 °C | 30 min | 0 | 0.46 |
Base degradation | 0.1 N NaOH, 25 °C | 5 min | 75.45 | 0.46 |
Acid degradation | 0.1 N HCl, 70 °C | 30 min | 64.84 | 0.39 |
Oxidative stress degradation | 3% H2O2, 70 °C | 30 min | 81.08 | 0.43 |
Dry heat degradation | 70 °C | 2 h | 98.62 | - |
Photolytic degradation | UV light | 24 h | 99.03 | - |