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Table 9 Summary of degradation data of SIT and ERT

From: Novel stability-indicating RP-UPLC method for simultaneous estimation of sitagliptin and ertugliflozin in bulk and pharmaceutical formulations

Degradation condition

% Degradation

Rt (min) of degradation products

SIT

ERT

Peak 1

Acid (0.5N/60°C/1hr)

8.8

10.5

1.366

Base (0.5N/60°C/1hr)

6.1

9.7

1.108

Oxidative (10%w/v H2O2/60°C/1hr)

8.1

6.2

1.011

Hydrolytic (water/60°C/1hr)

1.8

1

Thermal (105°C/1 day)

8.4

11.1

1.026

Photolytic (UV radiation at 200-Wh/m2-dark control)

8.2

11.3

  1. SIT sitagliptin, ERT ertugliflozin, hr hour, % percentage, Rt retention time, % percentage, UV ultraviolet, min minute, N normality, °C, degree Celsius, Wh/m2 Watt-hour per square meter