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Table 9 Summary of degradation data of SIT and ERT

From: Novel stability-indicating RP-UPLC method for simultaneous estimation of sitagliptin and ertugliflozin in bulk and pharmaceutical formulations

Degradation condition % Degradation Rt (min) of degradation products
SIT ERT Peak 1
Acid (0.5N/60°C/1hr) 8.8 10.5 1.366
Base (0.5N/60°C/1hr) 6.1 9.7 1.108
Oxidative (10%w/v H2O2/60°C/1hr) 8.1 6.2 1.011
Hydrolytic (water/60°C/1hr) 1.8 1
Thermal (105°C/1 day) 8.4 11.1 1.026
Photolytic (UV radiation at 200-Wh/m2-dark control) 8.2 11.3
  1. SIT sitagliptin, ERT ertugliflozin, hr hour, % percentage, Rt retention time, % percentage, UV ultraviolet, min minute, N normality, °C, degree Celsius, Wh/m2 Watt-hour per square meter