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Table 6 Forced degradation results

From: Development and validation of stability-indicating RP-HPLC method for estimation of dalfampridine in bulk drug and tablet dosage form

Conditions % Assay Degradation achieved Purity angle Purity threshold
Control 97.1 0.198 0.262
Acid degradation (5N HCl) 91.0 6.1 0.185 0.259
Base degradation (5N NaOH) 88.5 8.6 0.201 0.262
Peroxide degradation (30% H2O2) 90.9 6.2 0.690 0.243
Thermal degradation 96.0 1.1 0.201 0.264
Control 102.8 0.584 0.254
Photolytic (open Perti plate) 95.5 7.3 0.607 0.252
Photolytic (close Petri plate) 97.7 5.1 0.620 0.256
Photolytic (close Petri plate with aluminum foil) 100.3 2.5 0.610 0.253