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Table 6 Forced degradation results

From: Development and validation of stability-indicating RP-HPLC method for estimation of dalfampridine in bulk drug and tablet dosage form

Conditions

% Assay

Degradation achieved

Purity angle

Purity threshold

Control

97.1

0.198

0.262

Acid degradation (5N HCl)

91.0

6.1

0.185

0.259

Base degradation (5N NaOH)

88.5

8.6

0.201

0.262

Peroxide degradation (30% H2O2)

90.9

6.2

0.690

0.243

Thermal degradation

96.0

1.1

0.201

0.264

Control

102.8

0.584

0.254

Photolytic (open Perti plate)

95.5

7.3

0.607

0.252

Photolytic (close Petri plate)

97.7

5.1

0.620

0.256

Photolytic (close Petri plate with aluminum foil)

100.3

2.5

0.610

0.253