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Table 3 Half-life (t1/2) and rate constant (k) at different pH and temperature

From: Evaluation of physicochemical stability and degradation kinetics of bedaquiline in hydrolytic solutions of different pH

Parameters Temperature (°C)
25 50 80
Acidic pH (HCl)
 Rate constant (k)
  0.1 N 0.00184 0.00230 0.00322
  1 N 0.00392 0.00576 0.00643
  2 N 0.00507 0.00668 0.00748
 Half-life (t1/2) min
  0.1 N 376.14 300.91 214.94
  1 N 177.01 120.36 107.85
  2 N 136.78 103.76 92.59
Alkaline pH (NaOH)
 Rate constant (k)
  0.1 N 0.00138 0.00184 0.00230
  1 N 0.00184 0.00230 0.00276
  2 N 0.00368 0.00484 0.00553
 Half-life (t1/2) min
  0.1 N 501.52 376.14 300.91
  1 N 376.14 300.91 250.76
  2 N 188.07 143.29 125.38