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Table 3 Half-life (t1/2) and rate constant (k) at different pH and temperature

From: Evaluation of physicochemical stability and degradation kinetics of bedaquiline in hydrolytic solutions of different pH

Parameters

Temperature (°C)

25

50

80

Acidic pH (HCl)

 Rate constant (k)

  0.1 N

0.00184

0.00230

0.00322

  1 N

0.00392

0.00576

0.00643

  2 N

0.00507

0.00668

0.00748

 Half-life (t1/2) min

  0.1 N

376.14

300.91

214.94

  1 N

177.01

120.36

107.85

  2 N

136.78

103.76

92.59

Alkaline pH (NaOH)

 Rate constant (k)

  0.1 N

0.00138

0.00184

0.00230

  1 N

0.00184

0.00230

0.00276

  2 N

0.00368

0.00484

0.00553

 Half-life (t1/2) min

  0.1 N

501.52

376.14

300.91

  1 N

376.14

300.91

250.76

  2 N

188.07

143.29

125.38