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Table 2 In vivo hemostatic potential of individual test gums and their comparison with negative and positive control (data are expressed as mean±SD; **p<0.01)

From: Pharmacological comparison of four biopolymeric natural gums as hemostatic agents for management of bleeding wounds: preliminary in vitro and in vivo results

Parameters Negative Control Positive control
(SurgisponTM)
Gum tragacanth
(sponge)
Gum tragacanth
(powder)
Xanthan gum
(sponge)
Xanthan gum
(powder)
Guar gum
(sponge)
Guar gum
(powder)
Gum acacia
(sponge)
Gum acacia
(powder)
No. of animals 6 6 6 6 6 6 6 6 6 6
Initial wt. of sponge dressing before application (g) 0.08 ± 0.01 0.12 ± 0.01 0.49 ± 0.01 N/A 0.18 ± 0.01 N/A 0.23 ± 0.01 N/A 0.52 ± 0.01 N/A
Final wt. of sponge dressing after application (g) 1.02 ± 0.08 0.62 ± 0.07 0.63 ± 0.07 N/A 0.74 ± 0.05 N/A 0.88 ± 0.05 N/A 0.81 ± 0.09 N/A
Amount of blood absorbed by dressing (g) 0.94 ± 0.09 0.60 ± 0.09 0.14 ± 0.09** N/A 0.56 ± 0.05** N/A 0.65 ± 0.05 N/A 0.29 ± 0.08** N/A
Time for hemostasis (s) 557.2 ± 32.07 333.3 ± 38.84 156.2 ± 12.86** 76.00 ± 12.55** 252.2 ± 26.64** 148.5± 11.98** 322.7 ± 26.51 280.3 ± 20.05** 235.2 ± 12.67** 258.7± 28.61**
Adherence strength of test agent Low Low Moderate High Low High Low Moderate Low Low
Incidence of re-bleeding Yes Yes No No Yes No No Yes No Yes
Survival of animal Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes