Skip to main content

Table 2 In vivo hemostatic potential of individual test gums and their comparison with negative and positive control (data are expressed as mean±SD; **p<0.01)

From: Pharmacological comparison of four biopolymeric natural gums as hemostatic agents for management of bleeding wounds: preliminary in vitro and in vivo results

Parameters

Negative Control

Positive control

(SurgisponTM)

Gum tragacanth

(sponge)

Gum tragacanth

(powder)

Xanthan gum

(sponge)

Xanthan gum

(powder)

Guar gum

(sponge)

Guar gum

(powder)

Gum acacia

(sponge)

Gum acacia

(powder)

No. of animals

6

6

6

6

6

6

6

6

6

6

Initial wt. of sponge dressing before application (g)

0.08 ± 0.01

0.12 ± 0.01

0.49 ± 0.01

N/A

0.18 ± 0.01

N/A

0.23 ± 0.01

N/A

0.52 ± 0.01

N/A

Final wt. of sponge dressing after application (g)

1.02 ± 0.08

0.62 ± 0.07

0.63 ± 0.07

N/A

0.74 ± 0.05

N/A

0.88 ± 0.05

N/A

0.81 ± 0.09

N/A

Amount of blood absorbed by dressing (g)

0.94 ± 0.09

0.60 ± 0.09

0.14 ± 0.09**

N/A

0.56 ± 0.05**

N/A

0.65 ± 0.05

N/A

0.29 ± 0.08**

N/A

Time for hemostasis (s)

557.2 ± 32.07

333.3 ± 38.84

156.2 ± 12.86**

76.00 ± 12.55**

252.2 ± 26.64**

148.5± 11.98**

322.7 ± 26.51

280.3 ± 20.05**

235.2 ± 12.67**

258.7± 28.61**

Adherence strength of test agent

Low

Low

Moderate

High

Low

High

Low

Moderate

Low

Low

Incidence of re-bleeding

Yes

Yes

No

No

Yes

No

No

Yes

No

Yes

Survival of animal

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes