Skip to main content

Table 1 Independent and dependent variables used in Box–Behnken design for the development and optimization of NI

From: Design and optimization of nano invasomal gel of Glibenclamide and Atenolol combination: in vitro and in vivo evaluation

Factor Level used, actual coded
Independent variables Low (− 1) Medium (− 1) High (+ 1)
X1 = Phospholipid (mg) 9 11.5 14
X2 = Ethanol (%) 5 7.5 10
X3 = Terpene (%) 1 1.5 2
Dependent variables    Goal
% EE of GLB (Y1)    Maximize
% EE of ATN (Y2)    Maximize
Flux of GLB (Y3)    Maximize
Flux of ATN (Y4)    Maximize