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Table 1 Independent and dependent variables used in Box–Behnken design for the development and optimization of NI

From: Design and optimization of nano invasomal gel of Glibenclamide and Atenolol combination: in vitro and in vivo evaluation

Factor

Level used, actual coded

Independent variables

Low (− 1)

Medium (− 1)

High (+ 1)

X1 = Phospholipid (mg)

9

11.5

14

X2 = Ethanol (%)

5

7.5

10

X3 = Terpene (%)

1

1.5

2

Dependent variables

  

Goal

% EE of GLB (Y1)

  

Maximize

% EE of ATN (Y2)

  

Maximize

Flux of GLB (Y3)

  

Maximize

Flux of ATN (Y4)

  

Maximize