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Table 2 Effect of PNFC and PNFEA fractions on SGPT, SGOT, SALP, and total and direct bilirubin in CCl4-induced rats

From: Hepatoprotective activity of Phyllanthus niruri Linn. endophytes

Groups

Dose (mg/kg)

SGPT (mg/dl)

SGOT (mg/dl)

SALP (mg/dl)

Total bilirubin (mg/dl)

Direct bilirubin (mg/dl)

Control

2 ml/kg

39.10 ± 0.27

105 ± 0.67

458.1 ± 0.9

0.045 ± 0.007

0.015 ± 0.002

CCl4 treated

2 ml/kg

80.14 ± 0.13***

140 ± 6.73**

566.2 ± 0.4***

0.21 ± 0.019*

0.04 ± 0.004**

Silymarin

25 mg/kg

44.44 ± 2.08***

96.5 ± 0.9*

406.2 ± 1.1***

0.13 ± 0.010

0.018 ± 0.003

PNFC

50 mg/kg

50.75 ± 2.51***

111 ± 2.83*

336.7 ± 0.9***

0.12 ± 0.010

0.03 ± 0.002***

PNFC

100 mg/kg

42.66 ± 1.69***

103 ± 4.82**

434.32 ± 0.5***

0.09 ± 0.011*

0.013 ± 0.002

PNFEA

50 mg/kg

53.92 ± 1.35***

114 ± 0.10*

385.3 ± 0.8***

0.14 ± 0.014

0.03 ± 0.002

PNFEA

100 mg/kg

42.51 ± 2.41***

108 ± 1.83*

409.4 ± 0.68**

0.07 ± 0.005

0.02 ± 0.003

  1. The data were expressed as mean ± S.E.M. for six rats in each group. Statistical comparison was performed by one-way ANOVA followed by Turkey’s post test
  2. *P < 0.05, **P < 0.01, and ***P < 0.001 compared to normal control-treated group