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Table 7 Force degradation study results

From: Development and validation of stability-indicating RP-HPLC method for the simultaneous estimation of xylometazoline hydrochloride and ipratropium bromide from nasal spray dosage form

Stress degradation type Conditions Xylometazoline HCl Ipratropium bromide
Acid degradation 0.1N HCl 4.0% 13.80%
Base degradation 0.1N NaOH No degradation 18%
Oxidative degradation 30% H2O2 2.4% 6.70%
Thermal degradation At 80 °C for 48 h No degradation 6.0%