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Table 7 Results of forced degradation studies

From: Concurrent estimation of lamivudine, tenofovir disoproxil fumarate, and efavirenz in blended mixture and triple combination tablet formulation by a new stability indicating RP-HPLC method

Drug name

Standard

Acid hydrolysis

Base hydrolysis

Oxidative degradation

Photo degradation

Thermal degradation

Peak area of the solution

LAM

2,717,067

2,434,053

2,578,801

2,616,177

2,694,163

2,679,066

TDF

1,786,776

1,641,002

1,472,204

1,753,290

1,758,594

1,776,392

EVZ

1,235,921

1,177,547

1,055,922

1,194,572

1,212,763

1,222,960

% Degradation

LAM

-

10.4

5.0

3.7

0.85

1.4

TDF

-

8.1

17.6

1.87

1.58

0.6

EVZ

-

4.7

14.5

3.34

1.87

1.0

  1. Percentage degradation was less than 20% with different stress conditions