A review on association and correlation of genetic variants with eating disorders and obesity

Ahamed, Sayed Koushik; Barek, Md Abdul; Roy, Uthpall Kumar; Kouser, Md; Reza, Md Sharif; Mannan, Afifa Binthe; Alam, Md Ashraful; Uddin, S. M. Naim

doi:10.1186/s43094-021-00250-2

Future Journal of Pharmaceutical Sciences

Table 2 Overview of candidate gene findings in eating disorders

From: A review on association and correlation of genetic variants with eating disorders and obesity

Gene	Description	rs Number	References
HTR1D	Serotonin receptor 1D	rs6300	[51]
HTR1D	Serotonin receptor 1D	rs674386 rs856510	[52]
HTR2A	Serotonin receptor 2A	rs6311	[53,54,55,56]
HTR2C	Serotonin receptor 2C	rs6318	[57]
DRD2	Dopamine receptor D2	rs1799732	[58,59,60]
		rs6277	[59, 60]
		rs6278	[58]
		rs2283265	[60]
DRD3	Dopamine receptor D3	rs6280	[61]
DRD4	Dopamine receptor D4	rs1800955	[62]
COMT	Catechol-O-methyltransferase	rs4680	[63, 64]
ANKK1	Ankyrin repeat and kinase domain containing 1	rs1800497	[59, 60]
LEP	Leptin	rs13228377 rs7799039	[65]
LEPR	Leptin receptor	rs1137100 rs1137101	[65, 66]
LEPR	Leptin receptor	rs8179183	[66]
GHRL	Ghrelin	rs696217 rs4684677	[65, 67,68,69]
		rs34911341	[68, 69]
		rs2075356	[69]
MC4R	Melanocortin 4 receptor
		rs52820871	[70, 71]
		rs17782313	[65, 72]
		rs489693	[65]
AGRP	Agouti related protein	rs5030980	[65, 73]
AGRP	Agouti related protein	rs13338499	[65]
POMC	Proopiomelanocortin	rs1042571	[65]
ESR1	Estrogen receptor 1	rs726281 rs2295193 rs3798577	[74]
ESR1	Estrogen receptor 1	rs2234693 rs9340799	[75]
ESR2	Estrogen receptor 2	rs1256049	[75, 76]
		rs4986938	[75]
		rs928554	[77]
BDNF	Brain-derived neurotrophic factor	rs6265	[65, 78, 79]
BDNF	Brain-derived neurotrophic factor	rs56164415	[65, 78]
CNR1	Cannabinoid receptor 1	rs1049353	[80, 81]
OPRD1	Opioid receptor delta 1	rs536706 rs760589 rs204081	[51]
		rs569356 rs521809 rs4654327	[52]
		rs536706 rs204081	[51]
OPRM	Opioid receptor mu 1	rs1799971	[82]
FTO	Fat mass and obesity associated	rs9939609	[83, 84]
GHRL	Preproghrelin gene	rs696217 rs2075356	[69]
TPH2	Tryptophan hydroxylase 2	rs1473473	[85]
POMC	Pro-opiomelanocortin	rs24831852	[86]
NTRK3	Neurotrophic tyrosine kinase receptor type 3	rs7180942	[87]
FAAH	Fatty acid amide hydrolase	rs932816 rs324420 rs324419 rs873978 rs2295632	[80]
NAAA	N-acylethanolamine-hydrolyzing acid amidase	rs2292534 rs4859567 rs10518142 rs6819442	[80]
MGLL	Monoglyceride lipase	rs893294	[80]

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