Synthesis, characterization, and pharmacological evaluation of some metal complexes of quercetin as P-gp inhibitors

Future Journal of Pharmaceutical Sciences

Table 4 Apparent permeability coefficients (P_app) (× 10⁻⁶ cm/s) of atorvastatin in the everted duodenum of healthy rat small intestine (n = 3)

Time (min)	Duodenum
Time (min)	Atorvastatin-treated rats	Atorvastatin + verapamil-treated rats	Atorvastatin + Q-Cu complex-treated rats	Atorvastatin + Q-Co complex-treated rats	Atorvastatin + Q-Ni complex-treated rats
10	0.030 ± 0.003	0.028 ± 0.001	0.035 ± 0.001	0.035 ± 0.001	0.042 ± 0.001
30	0.036 ± 0.003	0.026 ± 0.002	0.024 ± 0.001	0.019 ± 0.001	0.027 ± 0.000
45	0.073 ± 0.019	0.022 ± 0.002*	0.023 ± 0.001*	0.012 ± 0.001**	0.020 ± 0.001*
60	0.119 ± 0.060	0.010 ± 0.002***	0.021 ± 0.001***	0.010 ± 0.0004***	0.009 ± 0.0001***

All values expressed as mean ± SD. *p < 0.05 significant, **p < 0.01 highly significant, ***p < 0.001 very highly significant, compared to atorvastatin control