Synthesis, characterization, and pharmacological evaluation of some metal complexes of quercetin as P-gp inhibitors

Future Journal of Pharmaceutical Sciences

Table 5 Apparent permeability coefficients (P_app) (× 10⁻⁶ cm/s) of atorvastatin in the everted jejunum of healthy rat small intestine (n = 3)

Time (min)	Jejunum
Time (min)	Atorvastatin-treated rats	Atorvastatin + verapamil-treated rats	Atorvastatin + Q-Cu complex-treated rats	Atorvastatin + Q-Co complex-treated rats	Atorvastatin + Q-Ni complex-treated rats
10	0.034 ± 0.004	0.032 ± 0.002	0.027 ± 0.001	0.028 ± 0.001	0.031 ± 0.001
30	0.042 ± 0.004	0.028 ± 0.002	0.022 ± 0.002	0.017 ± 0.002	0.022 ± 0.001
45	0.078 ± 0.019	0.026 ± 0.003	0.020 ± 0.002*	0.012 ± 0.001*	0.016 ± 0.001*
60	0.131 ± 0.074	0.023 ± 0.004**	0.019 ± 0.002**	0.009 ± 0.0005**	0.007 ± 0.0002**

All values expressed as mean ± SD. *p < 0.05 significant, **p < 0.001 very highly significant, compared to atorvastatin control